Results 201 to 210 of about 7,084,111 (308)

Younger Brazilians hit by COVID-19 – What are the implications?

The Lancet Regional Health. Americas, 2021
Raphael Mendonça Guimarães, DSc PhD, Margareth Crisóstomo Portela, PhD, Daniel Antunes Maciel Villela, PhD, Gustavo Correa Matta, DSc, Carlos Machado de Freitas, DSc   +4 more
doaj   +1 more source

Preventable Differences in Recommended Outpatient COVID-19 Treatment Among Adults With COVID-19 in the United States. [PDF]

Med Care
Bournigal-Feliciano M, Graff N, Koumans EH, Shah MM, Woolfork MN, Lunsford NB, King H, Patel P, Hagen MB, Kappelman MD, Mayer KH, Thacker D, Arnold J, Carton TW, Draper C, Emerton D, Block J, Manns BJ, PCORnet Network Partners.   +18 more
europepmc   +1 more source

COVID-19: Thematic Guidance Work-based Learning (including placements/partnerships/ apprenticeships/study abroad) [PDF]

, 2020

core  

Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

Advanced Science, EarlyView.
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini, Taylor V. Brysgel, Ryan J. Rahman, Eno‐Obong Essien, Saw Y. Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N. Patel, Sachchidanand Tiwari, Carolann L. Espy, Fengyi Dong, Sabrina A. Santos‐De León, Anit Shah, Vladimir V. Shuvaev, Elizabeth D. Hood, Liam S. Chase, Drew Weissman, Jeremy B. Katzen, David B. Frank, Mariko L. Bennett, Oscar A. Marcos‐Contreras, Jacob W. Myerson, Vladimir R. Muzykantov, Sahily Reyes‐Esteves, Jacob S. Brenner   +24 more
wiley   +1 more source

Prevalence and predictors of critical COVID-19 pneumonia among patients with COVID-19 admitted at Nyarugenge major COVID-19 Referral Center in Rwanda. [PDF]

BMC Infect Dis
Paul MM, Raphael N, Menelas N, Deborah A, Bonaventure UJ, Pasteur D, Beata MM, Epaphrodite M, Valens H, Prosper N, Shomuyiwa DO, Samuel M, Eric R.   +12 more
europepmc   +1 more source

Research Brief: April 2020: COVID-19 and Social Mobility Impact Brief #1: School Shutdown [PDF]

, 2020
Cullinane, Carl, Montacute, Rebecca
core  

A Deep Representation Learning Method for Quantitative Immune Defense Function Evaluation and Its Clinical Applications

Advanced Science, EarlyView.
ImmuDef, a novel algorithm to quantitatively evaluate the anti‐infection immune defense function of an individual based on RNA‐seq data via a variational autoencoder (VAE) model. It is validated on 3200+ samples across four immune states with high accuracy. It can serve as a metric for disease severity and prognosis across pathogenic cohorts.
Zhen‐Lin Tan, Tao Luo, Yu Lin, Xiao‐Jun Wu, Wen‐Kang Shen, Jie Chen, Qian Lei, An‐Yuan Guo   +7 more
wiley   +1 more source

All‐PEG‐Like Block Copolymers Self‐Assemble into Stealth Nanocarriers for Drug Delivery

Advanced Science, EarlyView.
Self‐assembling nanoparticles composed entirely of POEGMA are engineered by exploiting side‐chain–dependent amphiphilicity and tunable thermoresponsive behavior. These single‐material nanocarriers encapsulate diverse hydrophobic drugs with high efficiency, retain therapeutic activity, improve in vivo efficacy, and evade anti‐PEG antibodies.
Parul Sirohi, Brooke E. Silverstein, Yulia Shmidov, Sonal Deshpande, Joy Tong, Yvonne Y. Ma, Chinmay S. Potnis, Soumen Saha, Xinghai Li, Max R. Ney, Sarah Y. Kim, Joshua J. Milligan, Lixin Fan, Matthew L. Becker, Daniel Reker, Ashutosh Chilkoti   +15 more
wiley   +1 more source

COVID-19: lessons from Brazil. [PDF]

Int J Epidemiol
Pearce N, Cerqueira-Silva T.
europepmc   +1 more source

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

Advanced Science, EarlyView.
Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv, Peng Chen, Xiaobin Dai, Hu Xu, Ziheng Li, Zelin Shan, Jinqian Li, Fenglin Guo, Yuanfang Chen, Jiayi Li, Yiqian Huang, Guizhi Dong, Yifan Jiang, Liang Chen, Xuanyu Nan, Hanjun Zhao, Kang Zhang, Shilong Fan, Yuanchen Dong, Dongsheng Liu, Xinquan Wang, Deli Huang, Xiaojing Pan, Chunying Chen, Zhihua Liu, Li‐Tang Yan, Qi Zhang, Linqi Zhang, Yuliang Zhao, Yuhe Renee Yang   +29 more
wiley   +1 more source