Results 131 to 140 of about 3,920,456 (232)

Transcriptomics of severe COVID-19. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Gusarova AA, Trifonova EA, Babovskaya AA, Gavrilenko MM, Stepanov VA.   +4 more
europepmc   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

CRISPR/Cas13a: Compensatory Target Activation Mechanism

Advanced Science, EarlyView.
CRISPR/Cas13a‐CTAM as a novel compensatory target activation mechanism that enables synergistic activation of Cas13a via two independently editable short RNA effectors. This dual‐effector system maintains enzymatic activity comparable to traditional single‐effector while significantly enhancing flexibility, sensitivity, and application scope.
Bowen Jiang, Tenghua Zhang, Yao Lu, Shujun Zhou, Wenjing Xiao, Shuming Pan, Nan Shi, Yan Sheng, Jiaming Hu   +8 more
wiley   +1 more source

COVID-19 and Pregnancy: Key Findings. [PDF]

Scand J Immunol
Lima GG, Segati AF, Oliveira GS, de Melo NS, da Cunha TN, De Gaspari E.   +5 more
europepmc   +1 more source

Structural Insights Into Man9 Recognition by the HIV Antibody 2G12 Revealed by Paramagnetic NMR

Advanced Science, EarlyView.
The HIV gp120 glycoprotein displays Man9 oligomannose structures that are recognized by the neutralizing antibody 2G12. Detailed characterization of the binding epitope in solution is important for immunogen design but remains challenging, since the signals of the terminal mannoses from the three arms of Man9 (D1, D2, and D3) cannot be distinguished in
Adrián Silva‐Díaz, Paola Oquist‐Phillips, Noelia de la Cruz, Inés Lera‐Lasso, Laura Castañar, Javier Rojo, Javier Ramos‐Soriano, Ángeles Canales   +7 more
wiley   +1 more source

Thalidomide combined with low‐dose short‐term glucocorticoid in the treatment of critical Coronavirus Disease 2019

Clinical and Translational Medicine, 2020
Chengshui Chen, Feng Qi, Keqing Shi, Yuping Li, Ji Li, Yongping Chen, Jingye Pan, Tieli Zhou, Xiangyang Lin, Jinsan Zhang, Yongde Luo, Xiaokun Li, Jinglin Xia   +12 more
doaj   +1 more source

Evaluation of the Effects of COVID-19 Infection and COVID-19 mRNA Vaccine on Ovarian Reserve. [PDF]

J Clin Med
Basibuyuk Z, Cebi Basibuyuk C, Okumus S, Oncul M, Ocal KP.   +4 more
europepmc   +1 more source

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, EarlyView.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

COVID-19 Prophylactic Effect of Bromhexine Hydrochloride. [PDF]

Immun Inflamm Dis
Mitev V, Mondeshki T, Miteva A, Tachkov K, Dimitrova V.   +4 more
europepmc   +1 more source

QAA's advice to degree-awarding bodies on mitigating the disruption of studies to TNE students caused by the COVID-19 (Coronavirus) outbreak: March 2020 [PDF]

, 2020

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