Results 151 to 160 of about 2,049,788 (258)

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Catching a Break: Accessibility, Empathy, and COVID-19 [PDF]

, 2020
Clair E. Irwin
openalex   +1 more source

Clearance of Lormetazepam, Midazolam, and Their Conjugated Metabolites by Continuous Venovenous Hemofiltration During Prolonged Sedation in Critically Ill Patients With COVID‐19‐Associated Acute Respiratory Distress Syndrome [PDF]

, 2021
Kimberly N. Shudofsky, Paddy K.C. Janssen, Norbert A. Foudraine, Jos L.M.L. le Noble   +3 more
openalex   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Pregnancy in the Shadow of Covid-19: A Qualitative Study. [PDF]

Health Expect
Ozgoli G, Mobarakabadi SS.
europepmc   +1 more source

Rapid Decentralized Prostate Cancer Risk Stratification by Portable Liquid Biopsy Analysis within a Clinical Biosensor Validation Framework

Advanced Science, EarlyView.
In this work, we showcased two significant scientific advances in (i) developing a portable biosensor technology for rapid decentralized prostate cancer urinary biomarker testing and reporting, with superior performance to current clinical testing practice; and (ii) proposing a clinical validation framework (for our biosensor development) which can be ...
Kevin M. Koo, Grant Phillips, Sriganesh Srihari, Áine Farrell, Binny Jaradi, Kira J. Fitzpatrick, John W. Yaxley, Hemamali Samaratunga, Paul N. Mainwaring, Ke‐lin Ru, Darren J. Korbie, Scott A. Tomlins, Matthew J. Roberts, Robert A. Gardiner, Matt Trau   +14 more
wiley   +1 more source

Monitoring COVID-19 occurrence in a resource-limited setting - COVID-19 sentinel surveillance in Malawi. [PDF]

PLOS Glob Public Health
Ulaya G, Kabaghe A, Saussier C, MacLachlan E, Smith-Sreen J, Katumbi C, Bello G, Tafatatha T, Chaponda L, Mvula B, Kagoli M, Chilima B, Bitilinyu-Bangoh J, Chisuwo L, Babaye Y, Chitenje M, Bighignoli B, Bangara F, Namakhoma I, Chauma-Mwale A, O'Malley G, Mirkovic K, Wadonda-Kabondo N.   +22 more
europepmc   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

COVID-19 AND THE ACCOUNTING PROFESSION

, 2021
Wendy Heltzer, Mary Mindak
openalex   +2 more sources

Epidemiologic and Clinical Characteristics of Patients with Covid-19 in Central Java, Indonesia [PDF]

, 2020
Dwi Sutiningsih, Vilianti Eka Fitri Rahatina, Yulianto Prabowo, Aris Haryanto, Mufti Agung Wibowo   +4 more
openalex   +1 more source