Results 161 to 170 of about 2,049,788 (258)

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

Thalidomide combined with low‐dose short‐term glucocorticoid in the treatment of critical Coronavirus Disease 2019

Clinical and Translational Medicine, 2020
Chengshui Chen, Feng Qi, Keqing Shi, Yuping Li, Ji Li, Yongping Chen, Jingye Pan, Tieli Zhou, Xiangyang Lin, Jinsan Zhang, Yongde Luo, Xiaokun Li, Jinglin Xia   +12 more
doaj   +1 more source

A Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines

Advanced Science, EarlyView.
OncoLRC, a one‐component lipid‐mRNA complex, enables efficient spleen‐targeted delivery at an exceptionally low lipid‐to‐mRNA mass ratio (1.5:1), robustly activates immune responses, inhibits tumor growth, and synergizes with checkpoint blockade, presenting a next‐generation platform for mRNA vaccines.
Qimeng Yin, Chenchen Zhang, Jiahao Li, Kun Huang, Min Qiu   +4 more
wiley   +1 more source

Marked Sinus Bradycardia in a COVID-19 Patient. [PDF]

Case Rep Cardiol
Valladares C, Kaplan A.
europepmc   +1 more source

COVID-19: Psychological Effects of the Pandemic. How to Help Healthcare Workers? [PDF]

, 2020

openalex   +1 more source

Host‐Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules

Advanced Science, EarlyView.
Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun, Sumin Son, JinAh Lee, Minha Lee, Meehyun Ko, Songrui Zhao, Ju Hee Kim, Kannan Vaithegi, Ji Hoon Kwon, Jung Ho Lee, Sangeun Jeon, Dawon Yi, Peng Zou, Seungtaek Kim, Seung Bum Park   +14 more
wiley   +1 more source

Public health challenges posed by delays in obtaining COVID-19 clearance for long-distance truckers across East Africa

Global Epidemiology, 2020
John Gachohi, Jane Aduda, Reuben Thuo, Joseph Mung'atu, Fred Wamunyokoli, Thomas Ngigi, Henry Athiany, Gideon Kikuvi, Susan Mambo, Wairimu Gichaiya, Joseph Matheri, Patrick Mburugu, Justus Simba, Carol Otiwa, Charles Muriuki, Joshua Mwaura, May Yariwo, Beatrice Kariuki, Joseph Machua, Catherine Mwangi, Patrick Amoth, Rashid Aman, Onesmus Kamau, Kennedy Muthoka, Jacob Otieno, Pascal Mwele, Rose Nzioka, Simon Karanja   +27 more
doaj   +1 more source

Younger Brazilians hit by COVID-19 – What are the implications?

The Lancet Regional Health. Americas, 2021
Raphael Mendonça Guimarães, DSc PhD, Margareth Crisóstomo Portela, PhD, Daniel Antunes Maciel Villela, PhD, Gustavo Correa Matta, DSc, Carlos Machado de Freitas, DSc   +4 more
doaj   +1 more source

Preventable Differences in Recommended Outpatient COVID-19 Treatment Among Adults With COVID-19 in the United States. [PDF]

Med Care
Bournigal-Feliciano M, Graff N, Koumans EH, Shah MM, Woolfork MN, Lunsford NB, King H, Patel P, Hagen MB, Kappelman MD, Mayer KH, Thacker D, Arnold J, Carton TW, Draper C, Emerton D, Block J, Manns BJ, PCORnet Network Partners.   +18 more
europepmc   +1 more source

⁠Engineering Adaptive Immunity in 3D: A Patient‐Specific Lymphoid Model Using Stromal Networks and Peripheral Blood Mononuclear Cells

Advanced Science, EarlyView.
This study presents a 3D lymphoid tissue model engineered from adipose‐derived stem cells differentiated into fibroblastic reticular cell–like networks and co‐cultured with immune cells. The engineered system successfully generates antigen‐specific antibodies and cytokine responses, providing a platform for studying adaptive immunity, vaccine efficacy,
Mei ElGindi, Shaza Karaman, Jeremy Teo
wiley   +1 more source