Results 211 to 220 of about 5,127,009 (325)

NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis

Advanced Science, EarlyView.
Host E3 ligase FBXO5 as a key regulator that promotes K48‐linked ubiquitination and proteasomal degradation of SARS‐CoV‐2 NSP7, thereby suppressing viral replication. NSP7 ubiquitination is co‐regulated by β‐TrCP1 and TAF1. Small molecule BC24877 disrupts β‐TrCP1‐mediated degradation of FBXO5, stabilizing FBXO5 and enhancing NSP7 clearance ...
Yao Tong, Travis B. Lear, Ferhan Tuncer, John J. Villandre, Áine N. Boudreau, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Daniel P. Camarco, Mads B. Larsen, Yun Hua, Yanwen Chen, Meigin E. Chandler, Ricardo Pineda, Simon M. Barratt‐Boyes, John W. Evankovich, Toren Finkel, Yuan Liu, Bill B. Chen   +18 more
wiley   +1 more source

Age and gender patterns in COVID-19: Insights from a Regional COVID-19 testing center. [PDF]

J Family Med Prim Care
Franks AM, Holbert D, West J, Trent E, Parker J, Wellman C, Korkmaz A, Bannister T.   +7 more
europepmc   +1 more source

Cytokine Storm Induction Linked to Multi‐Organ Failure in Fatal Jellyfish Stings

Advanced Science, EarlyView.
N. nomurai is the most important injurious species in the coastal area of China. Model construction, omics analysis, mechanism exploration, and intervention measures of N. nomurai envenomation are performed in the current study, and it suggested that cytokine storm played an important role in pathogenesis.
Yichao Wang, Yi Wang, Fengling Yang, Jingbo Chen, Xiaoyu Geng, Qing Sun, Jinyu Zhang, Chang Liu, Jie Lv, Xiaochuan Hou, Yongfang Wang, Huiyan Lin, Jing Zhang, Lingxin Chen, Bing Yan, Liang Xiao   +15 more
wiley   +1 more source

COVID-19 Vaccine Hesitancy, Self-Reported Adverse Events, and Determinants Among Ethiopian Healthcare Professionals During COVID-19 Pandemic. [PDF]

Public Health Chall
Abiye AA, Endale S, Negash Z, Hussen SU, Gebregeorgise DT, Tamiru MT, Beyene DA, Amde HS, Negash AY.   +8 more
europepmc   +1 more source

AN EXAMINATION OF THE DIFFERENCE BETWEEN TRADITIONAL AND DIGITAL STORYTELLING THROUGH A VIDEO FILM ON MASK USE IN THE COVID 19 PANDEMIC PROCESS GELENEKSEL VE DİJİTAL HİKAYE ANLATICILIĞI ARASINDAKİ FARKIN COVİD 19 PANDEMİ SÜRECİNDE MASKE KULLANIMINA İLİŞKİN BİR VİDEO FİLMİ ÜZERİNDEN İNCELENMESİ

, 2017
Gözde SUNAL, Duygu FURUNCU KUTLUHAN, Seda BAĞDATLI KALKAN   +2 more
openalex   +1 more source

A Glycoproteome Data Mining Strategy for Characterizing Structural Features of Altered Glycans with Thymic Involution

Advanced Science, EarlyView.
This study presents a comprehensive data mining strategy for in‐depth extraction of overall and altered glycan features from structural and site‐specific glycoproteome data across various biomedical samples. The strategy enables the uncovery of four major altered glycan features associated with thymic involution and reveals their coordinated ...
Zhida Zhang, Yongqi Wu, Ke Hou, Yiwen Zhang, Lin Chen, Muyao Yang, Zhehui Jin, Yongchao Xu, Yingjie Zhang, Yinli Cai, Jiayu Zhao, Shisheng Sun   +11 more
wiley   +1 more source

Tracking the financial flows of Indonesia's COVID-19 vaccination program. [PDF]

PLOS Glob Public Health
Herlinda O, Larasanti A, Sumulyo SAK, Jundullah SM, Mambea IY.   +4 more
europepmc   +1 more source

COVİD-19 ile Mücadelede Türk Mutfağının Önemi The Importance of Turkish Cuisine in Fighting COVID-19

, 2017
Nurten ÇEKAL, Hatice AKTÜRK
openalex   +1 more source

PFKFB2‐Driven Glycolysis Promotes Dendritic Cell Maturation and Exacerbates Acute Lung Injury

Advanced Science, EarlyView.
Paraquat (PQ) or lipopolysaccharide (LPS) exposure activates the HIF‐1α–PFKFB2 pathway, driving glycolysis in dendritic cells (DCs). This metabolic shift enhances DC maturation and immune activation, exacerbating acute lung injury (ALI). This study demonstrates that PFKFB2‐driven glycolytic reprogramming in DCs plays a critical role in the pathogenesis
Ding Yuan, Fang Yang, Linlin Hou, Yan Zhang, Xin Pang, Yuqi Du, Hongyi Yan, Huanzhou Zhu, Yue Cheng, Yue Wu, Pinpin Jiang, Mengnan Guo, Mengying Zhang, Jinjie Guo, Huihui Hao, Yong Jiang, Yi Li, Yanxia Gao   +17 more
wiley   +1 more source

The Role of Comorbidities in COVID-19 Severity. [PDF]

Viruses
König S, Vaskyte U, Boesing M, Lüthi-Corridori G, Leuppi JD.   +4 more
europepmc   +1 more source