Results 121 to 130 of about 1,518,675 (340)

[COVID-19 vaccine safety].

Revista peruana de medicina experimental y salud publica, 2021
The development and production of safe and effective vaccines against coronavirus disease 2019 (COVID-19) provides hope for controlling the current pandemic. Adverse events following immunization are unwanted responses or unintended events that must be carefully monitored, as all vaccines, including those developed against SARS-CoV-2, are required to ...
Nataniel Aldo Chaparro Mérida, Dayany Moreno Samper, Alex Omar Franco Lacato   +2 more
openaire   +2 more sources

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

COVID-19 vaccine uptake and vaccine hesitancy in rural-to-urban migrant workers at the first round of COVID-19 vaccination in China

BMC Public Health, 2023
Background Migration can be linked to the transmission of COVID-19. COVID-19 vaccine uptake and hesitancy among rural-to-urban migrant workers in China, the largest group of internal migrants in the world, has not been characterized.
Liuzhi Hong, Zhou Jin, Kewei Xu, Guanghui Shen, Yang Zou, Ran Li, Lu Xu, Dexuan Wang, Li Chen, Yili Wu, Weihong Song   +10 more
doaj   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

Henoch–Schönlein purpura following COVID‐19 vaccine

JEADV Clinical Practice
Henoch–Schönlein purpura (HSP) is an immunoglobulin A (IgA)‐mediated small‐vessel vasculitis mostly observed in children and rarely in adults. It can affect many organs, mainly the skin, kidneys, joints, and gastrointestinal tract.
Nesrine Ben Salah, Maha Lahouel, Lella Douh, Khaoula Trimeche, Amina Aounallah, Amira Atig, Colandane Belajouza, Mohamed Denguesli   +7 more
doaj   +1 more source

Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial

The Lancet, 2020
Background This is the first randomised controlled trial for assessment of the immunogenicity and safety of a candidate non-replicating adenovirus type-5 (Ad5)-vectored COVID-19 vaccine, aiming to determine an appropriate dose of the candidate vaccine ...
F. Zhu, X. Guan, Yu-Hua Li, Jianying Huang, T. Jiang, L. Hou, Jing-xin Li, Beifang Yang, Ling Wang, Wenjuan Wang, Shipo Wu, Zhao Wang, Xiao-Hong Wu, Junjie Xu, Zhe Zhang, S. Jia, Busen Wang, Y. Hu, Jingjing Liu, Jun Zhang, X. Qian, Qiong Li, H. Pan, Hudachuan Jiang, P. Deng, J. Gou, Xuewen Wang, Xinglong Wang, Wei Chen   +28 more
semanticscholar   +1 more source

Differences in SARS‐CoV‐2 Antigen Persistence in Individuals With Systemic Autoimmune Rheumatic Diseases Compared to the General Population: A RECOVER‐Adult Cohort Study

Arthritis &Rheumatology, EarlyView.
Objective Individuals with systemic autoimmune rheumatic diseases (SARDs) are at risk for worse acute and post–acute COVID‐19 outcomes, though whether individuals with SARDs have longer persistence of viral antigens after COVID‐19 has not been studied.
Naomi J. Patel, Zoe Swank, Jiaqi Wang, Xiaosong Wang, Lauren A. O'Keeffe, Madison Negron, Liya S. Getachew, Louise L. Hansen, Grace Qian, Alene A. Saavedra, Kevin T. Mueller, Natalie A. Davis, Kathleen M. M. Vanni, Sandria Savage, Julie S. Lam, Zachary S. Wallace, David R. Walt, Jeffrey A. Sparks, on behalf of RECOVER‐Adult   +18 more
wiley   +1 more source

Research progress on sequential immunization strategies of COVID-19 vaccines: a review

Zhongguo gonggong weisheng
The global pandemic of the coronavirus disease 2019 (COVID-19) has had a serious impact on global life safety and economic development. Vaccination with the coronavirus disease vaccine (COVID-19 vaccine) is an important measure to prevent infection ...
Rongrong DAI, Hangjie ZHANG, Jianmin JIANG   +2 more
doaj   +1 more source

Acceptance and willingness to pay for COVID-19 vaccine among school teachers in Gondar City, Northwest Ethiopia

Tropical Medicine and Health, 2021
Background Vaccination is one of the strategies to prevent the COVID-19 pandemic. COVID-19 vaccine acceptance and cost are important factors affecting its uptake.
Kegnie Shitu, Meareg Wolde, Simegniew Handebo, Ayenew Kassie   +3 more
doaj   +1 more source

Through the lens of marketing authorization holders: experience in use of real‐world data and real‐world evidence in drug development and regulatory submissions in EU

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim The aim of this study was to assess the general and product‐specific experiences of MAHs use of RWD/RWE in medicines development and in their regulatory submissions, and to explore organizational aspects of MAHs related to RWD/RWE. Methods An electronic survey was conducted, and information collected directly from MAHs.
Sini M. Eskola, Aleksandar Gigov, Hubertus G. M. Leufkens, Andrew Bate, Marie Louise De Bruin, Helga Gardarsdottir   +5 more
wiley   +1 more source