Results 231 to 240 of about 1,518,675 (340)

COVID-19 vaccine immunogenicity in Mongolian adults with and without chronic hepatitis. [PDF]

open access: yesBMC Infect Dis
Callier V   +9 more
europepmc   +1 more source

Polyglycerol‐Based Lipids: A Next‐Generation Alternative to PEG in Lipid Nanoparticles for Advanced Drug Delivery Systems

open access: yesMacromolecular Rapid Communications, EarlyView.
Linear polyglycerol is proposed as a PEG‐alternative in mRNA‐loaded lipid nanoparticles to limit activation of anti‐PEG antibodies and reduce immunogenicity. Resulting nanoparticles may provide similar gene delivery capabilities, while preventing binding of anti‐PEG antibodies compared to PEGylated counterparts.
Yara Ensminger   +8 more
wiley   +1 more source

Aliphatic Poly(Carbonate)s with Acid Responsive Release Mechanisms for Micellar Anti‐Tumor Drug Delivery

open access: yesMacromolecular Rapid Communications, EarlyView.
Micellar systems based on biodegradable aliphatic polycarbonates and acid‐responsive triggers enhance drug solubility, stability, and tumor‐selective release. This review covers micelles with acid‐cleavable drug linkages and those that disassemble via acid‐sensitive functionalities.
Adrian V. Hauck, Lutz Nuhn
wiley   +1 more source

Effectiveness of COVID-19 Vaccine Boosters in Children Across Pandemic and Endemic Periods. [PDF]

open access: yesMicroorganisms
Oliveira EA   +14 more
europepmc   +1 more source

Diverging Cervical Cancer Burden in Africa in the Context of WHO's Elimination Strategy: Insights From GBD 2023

open access: yesMed Research, EarlyView.
The study highlights the rising cervical cancer burden in Africa, where rates have increased since 1990. Key challenges include structural health inequalities, low HPV vaccination coverage, and limited screening. Projections suggest a continued increase in incidence, deaths, and DALYs by 2038, diverging further from global trends.
Yedong Huang   +18 more
wiley   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

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