Results 61 to 70 of about 6,183,390 (300)

Etoposide as Salvage Therapy for Cytokine Storm due to COVID-19

, 2020
Coronavirus disease 2019 (COVID-19) has resulted in significant morbidity and mortality because of a lack of effective therapies. Therapeutic strategies under investigation target the overactive cytokine response with anti-cytokine or immunomodulators ...
Bromberg, Michael, Criner, Gerard J., 0000-0002-1828-6524, 0000-0003-2402-1351, Caricchio, Roberto, Patel, Maulin, Sacher, Daniel, Desai, Parag, Chandar, Ashwin, Dominguez Castillo, Eduardo, 0000-0002-1379-1118   +10 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Pfizer-BioNTech mRNA Vaccine Protection among Children and Adolescents Aged 12–17 Years against COVID-19 Infection in Qatar

Vaccines, 2023
Qatar was also hit hard by the global pandemic of SARS-CoV-2, with the original virus, Alpha variant, Beta variant, Omicron BA.1 and BA.2 variants, Omicron BA.4 and BA.5 variants, and Delta variant, sequentially.
Khadieja Osman, Jesha Mundodan, Juel Chowdhury, Rejoice Ravi, Rekayahouda Baaboura, Jeevan Albuquerque, Bilal Riaz, Reem Yusuf Emran, Khatija Batoul, Abdul Mahmood Esameldin, Zinah Al Tabatabaee, Hayat Khogali, Soha Albayat   +12 more
doaj   +1 more source

Preliminary predictive criteria for COVID-19 cytokine storm

, 2020
Objectives: To develop predictive criteria for COVID-19-associated cytokine storm (CS), a severe hyperimmune response that results in organ damage in some patients infected with COVID-19.
Bromberg, Michael, 0000-0003-4737-8003, Criner, Gerard J., Zhang, Xinyan, Gallucci, Marcello, Dass, Chandra, Caricchio, Roberto, Gallucci, Stefania, Fleece, David, 0000-0002-1379-1118   +9 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

COVID-19 Solution

International Journal of Preventive Medicine, 2020
Coronaviruses (CoV) are RNA viruses that cause endemic infections in various species of mammals and avian birds. There are seven known human CoVs, each of which causes respiratory diseases: together account for about one third of common colds. Some CoVs have recently entered humans from infected animals and lastly we have SARS COVID-19, (CoV), which ...
Roberto Menicagli, Mario Limodio
openaire   +3 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

A 2-month field cohort study of SARS-CoV-2 in saliva of BNT162b2 vaccinated nursing home workers

Communications Medicine, 2022
Saegerman et al. perform saliva SARS-CoV-2 testing in a cohort of nursing home workers in Belgium who are either unvaccinated or have received one or two doses of the BNT162b2 mRNA vaccine.
Claude Saegerman, Anh Nguyet Diep, Véronique Renault, Anne-Françoise Donneau, Lambert Stamatakis, Wouter Coppieters, Fabienne Michel, Christophe Breuer, Margaux Dandoy, Olivier Ek, Claire Gourzones, Joey Schyns, Emeline Goffin, Frédéric Minner, Keith Durkin, Maria Artesi, Vincent Bours, Fabrice Bureau, Laurent Gillet   +18 more
doaj   +1 more source

Homologación de vacunas contra la COVID-19: experiencia y desafíos desde su implementación en Chile

Revista Panamericana de Salud Pública, 2023
El objetivo de este artículo es describir la experiencia en el proceso de homologación de vacunas contra la COVID-19 en Chile durante los años 2021 y 2022, y los principales obstáculos durante su implementación.
Matías Santos-López, Francisco Alvear-Muñoz, Felipe Arévalo-Galdames, Vannia Díaz-Navarrete   +3 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source