Results 151 to 160 of about 614,587 (286)

Efficient estimation of a Cox model when integrating the subgroup incidence rate information. [PDF]

J Appl Stat, 2023
Su PF, Zhong J, Liu YC, Lin TH, Ou HT.
europepmc   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Variable Selection in Ultra-high Dimensional Feature Space for the Cox Model with Interval-Censored Data. [PDF]

J Stat Plan Inference
Pak D, Zhang J, Wu D, Weng H, Li C.
europepmc   +1 more source

Comparison of survival prediction models for pancreatic cancer: Cox model versus machine learning models. [PDF]

Genomics Inform, 2022
Kim H, Park T, Jang J, Lee S.
europepmc   +1 more source

First description of the Minnesota Earth System Model for Ocean biogeochemistry (MESMO 1.0)

, 2008
Here we describe the first version of the Minnesota Earth System Model for Ocean biogeochemistry (MESMO 1.0), an intermediate complexity model based on the Grid ENabled Integrated Earth system model (GENIE-1).
A. R. Price, Tokos, K.S., Matsumoto, K., K. S. Tokos, Cox, S.J., Price, A.R., S. J. Cox, K. Matsumoto   +7 more
core  

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Deep learning for the change-point Cox model with current status data. [PDF]

Lifetime Data Anal
Huang Q, Feng A, Wu Q, Tong X.
europepmc   +1 more source

ODACH: a one-shot distributed algorithm for Cox model with heterogeneous multi-center data. [PDF]

Sci Rep, 2022
Luo C, Duan R, Naj AC, Kranzler HR, Bian J, Chen Y.   +5 more
europepmc   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Incorporating external risk information with the Cox model under population heterogeneity: applications to trans-ancestry polygenic hazard scores. [PDF]

J R Stat Soc Ser A Stat Soc
Wang D, Ye W, Zhu J, Xu G, Tang W, Zawistowski M, Fritsche LG, He K.   +7 more
europepmc   +1 more source