Results 171 to 180 of about 614,587 (286)

Instrumental variable estimation of the marginal structural Cox model for time-varying treatments. [PDF]

Biometrika, 2023
Cui Y, Michael H, Tanser F, Tchetgen Tchetgen E.   +3 more
europepmc   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Survival prediction in triple-negative breast cancer: a Cox model with fairness assessment using ISO/IEC TR 24027:2021 in a MENA cohort. [PDF]

Explor Target Antitumor Ther
Alirezaei Farahani M, Sadeghipour F, Marateb HR, Soltan M, Naimi A, Mansourian M.   +5 more
europepmc   +1 more source

Fast Lasso method for large-scale and ultrahigh-dimensional Cox model with applications to UK Biobank. [PDF]

Biostatistics, 2022
Li R, Chang C, Justesen JM, Tanigawa Y, Qian J, Hastie T, Rivas MA, Tibshirani R.   +7 more
europepmc   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Prognostic prediction in schizophrenia using the Anderson-Gill time-dependent Cox model: a cohort study in a less-developed region of Southwest China. [PDF]

BMC Psychiatry
Tang W, Li M, Hou Z, Pu E, Cheng N, Deng L, He S, Men D, Huang J, Li Y, Wang Q, Yin J, Meng Q, Zhang T.   +13 more
europepmc   +1 more source

Adjusted Survival Curves Improve Understanding of Multivariable Cox Model Results. [PDF]

J Arthroplasty, 2021
Lundgreen CS, Larson DR, Atkinson EJ, Devick KL, Lewallen DG, Berry DJ, Maradit Kremers H, Crowson CS.   +7 more
europepmc   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Efficient estimation for the multivariate Cox model with missing covariates. [PDF]

Stat Neerl
Cho Y, Kim S, Ahn KW.
europepmc   +1 more source

Corrigendum to: Fast Lasso method for large-scale and ultrahigh-dimensional Cox model with applications to UK Biobank. [PDF]

Biostatistics, 2022
Li R, Chang C, Justesen JM, Tanigawa Y, Qian J, Hastie T, Rivas MA, Tibshirani R.   +7 more
europepmc   +1 more source