Biolipid Film‐Fused Electrochemiluminescence for Multipurpose In Situ Bioassays
Advanced Science, EarlyView.An ECL‐emissive, membrane‐interactive scaffold was fabricated, and facilely fused with natural and non‐native phospholipids into multifactorial mimicries of cytomembranes and vesicles for in vitro representative membrane‐process probing. Such a biointerface‐based, state‐sensitive ECL paradigm not only pinpointed proximal phenomena, including channeling
Jialiang Chen +9 more
wiley +1 more source
The Cox Model With Adaptive Fused Group Bridge Penalty to Incorporate Historical Data Into the Analysis of Clinical Trials With an Application to BMT CTN 1101. [PDF]
Stat MedFang X +4 more
europepmc +1 more source
Advanced Science, EarlyView.An integrated computational screening strategy identified ursolic acid (UA) and 18β‐glycyrrhetinic acid (18βGA) as a self‐assembling food‐derived molecular pair. The resulting carrier‐free nanoparticles (UA‐18βGA) showed synergistic antiparasitic activity, reduced combined toxicity, and host‐protective anti‐inflammatory effects in zebrafish and murine ...
Shenye Qu +8 more
wiley +1 more source
Restricted mean survival time approach versus time-varying coefficient Cox model for quantifying treatment effect when hazards are non-proportional. [PDF]
BMC Med Res MethodolGu T, Chen Z, Soon YY, Wee J, Tai BC.
europepmc +1 more source
Sustainable Synaptic Device with Two‐Dimensional Ferroelectric Materials for Neuromorphic Computing
Advanced Science, EarlyView.α‐In2Se3 based FeSFETs can be utilized as sustainable devices through polarization switching governed by both out‐of‐plane and in‐plane polarizations. Upon reaching a fatigued state, current annealing enabled by conductance modulation can significantly enhance the endurance of FeSFETs.
Jaewook Yoo +12 more
wiley +1 more source
Software Application Profile: CaseCohortCoxSurvival-an R package for case-cohort inference for relative hazard and pure risk under the Cox model. [PDF]
Int J EpidemiolEtiévant L, Gail MH.
europepmc +1 more source
Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation
Advanced Science, EarlyView.Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang +4 more
wiley +1 more source
Analyzing Left-Truncated Samples with the Cox Model in the Presence of Missing Covariates. [PDF]
Stat BiosciVazquez O, Locke HM, Xie SX.
europepmc +1 more source
Regularization Paths for Cox's Proportional Hazards Model via Coordinate Descent
We introduce a pathwise algorithm for the Cox proportional hazards model, regularized by convex combinations of l_1 and l_2 penalties (elastic net). Our algorithm fits via cyclical coordinate descent, and employs warm starts to find a solution along a ...
Trevor Hastie +3 more
core
Advanced Science, EarlyView.A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo +13 more
wiley +1 more source