Results 241 to 250 of about 1,478,952 (298)

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

Feline‐Inspired Robot Enabled by Combustion‐Driven Actuators for Agile Motion and High‐Payload Obstacle Traversal

Advanced Science, EarlyView.
Inspired by nature's competitive maneuvers, this study introduces a combustion‐driven soft actuator that powers a multi‐modal “Jump‐and‐Fly Catbot” (JFC). With millisecond response, high‐force output (over 70 times its weight) and precise control (error within 5%), the robot can jump, fly, hover, and escape from challenging environments, achieving ...
Hongkuan Ma, Yang Yang, Zhiguo He, Hongliang Ren, Pengcheng Jiao   +4 more
wiley   +1 more source

Inactivation Rap2a in Endothelial Cell Prevents Pulmonary Fibrosis by Regulating Immune Microenvironment Through MAP4K4‐VCAM1 Signaling

Advanced Science, EarlyView.
We identified the endothelial RAP2A as a regulator of inflammatory endothelial activation in experimental lung fibrosis and suggest that targeting RAP2A‐mediated signaling may represent a potential strategy to modulate endothelial–immune crosstalk during fibrotic lung injury.
Xiaolan Zheng, Peng Yue, Kaiyu Zhou, Guidong Gong, Yue Zhang, Sha Lin, Xu Liu, Yanjiang Zheng, Siyuan Jing, Junling Guo, Yan Qi, Bi‐Sen Ding, Yimin Hua, Yifei Li   +13 more
wiley   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Advanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai   +15 more
wiley   +1 more source

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Model selection among Dimension-Reduced generalized Cox models

Lifetime Data Analysis, 2022
Conventional semiparametric hazards regression models rely on the specification of particular model formulations, such as proportional-hazards feature and single-index structures. Instead of checking these modeling assumptions one-by-one, we proposed a class of dimension-reduced generalized Cox models, and then a consistent model selection procedure ...
Ming-Yueh Huang, Kwun Chuen Gary Chan
openaire   +2 more sources

Random effects Cox models: A Poisson modelling approach [PDF]

Biometrika, 2003
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Renjun Ma, Daniel Krewski, Richard T. Burnett   +2 more
openaire   +1 more source

A Non‐stationary Cox Model

Scandinavian Journal of Statistics, 2000
The purpose of this paper is to consider the problem of statistical inference about a hazard rate function that is specified as the product of a parametric regression part and a non‐parametric baseline hazard. Unlike Cox's proportional hazard model, the baseline hazard not only depends on the duration variable, but also on the starting date of the ...
Pons, O., Visser, M.
openaire   +3 more sources

Diagnostic Plots in Cox's Regression Model

Biometrics, 1991
Two diagnostic plots are presented for validating the fitting of a Cox proportional hazards model. The added variable plot is developed to assess the effect of adding a covariate to the model. The constructed variable plot is applied to detect nonlinearity of a fitted covariate. Both plots are also useful for identifying influential observations on the
Chen, Chen-Hsin, Wang, P. C.
openaire   +2 more sources

Weighted functional linear Cox regression model

Statistical Methods in Medical Research, 2021
The aim of this paper is to develop a weighted functional linear Cox regression model that accounts for the association between a failure time and a set of functional and scalar covariates. We formulate the weighted functional linear Cox regression by incorporating a comprehensive three-stage estimation procedure as a unified methodology. Specifically,
Hojin Yang, Hongtu Zhu, Mihye Ahn, Joseph G Ibrahim   +3 more
openaire   +2 more sources