Results 51 to 60 of about 14,803,607 (247)

Multivariate Cox proportional hazards model.

, 2016
Multivariate Cox proportional hazards model.
Wojciech Surtel (3325326), Teresa Małecka-Massalska (3325329), Radosław Mlak (3325320), Anna Brzozowska (1768099), Kamal Morshed (3325317), Agata Smoleń (3325323)   +5 more
core   +1 more source

Weighted Cox Regression Using the R Package coxphw

Journal of Statistical Software, 2018
Cox's regression model for the analysis of survival data relies on the proportional hazards assumption. However, this assumption is often violated in practice and as a consequence the average relative risk may be under- or overestimated.
Daniela Dunkler, Meinhard Ploner, Michael Schemper, Georg Heinze   +3 more
doaj   +1 more source

A Resampling Method to Improve the Prognostic Model of End-Stage Kidney Disease: A Better Strategy for Imbalanced Data

Frontiers in Medicine, 2022
BackgroundPrognostic models can help to identify patients at risk for end-stage kidney disease (ESKD) at an earlier stage to provide preventive medical interventions. Previous studies mostly applied the Cox proportional hazards model.
Xi Shi, Xi Shi, Tingyu Qu, Gijs Van Pottelbergh, Marjan van den Akker, Marjan van den Akker, Bart De Moor   +6 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Cox proportional hazards model results.

, 2018
Cox proportional hazards model results.
Donald R. Nelson (5040641), Michael R. Coughlan (5040644)   +1 more
core   +1 more source

Disability and the risk of subsequent mortality in elderly: a 12-year longitudinal population-based study

BMC Geriatrics, 2021
Background Assessment the impact of disability on mortality among the elderly is vital to healthy ageing. The present study aimed to assess the long-term influence of disability on death in the elderly based on a longitudinal study.
Yang Yang, Zhaohui Du, Yafei Liu, Jiahui Lao, Xiaoru Sun, Fang Tang   +5 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Testing Linear and Nonlinear Hypotheses in a Cox Proportional Hazards Model with Errors in Covariates

Lithuanian Journal of Statistics, 2019
We investigate linear and nonlinear hypotheses testing in a Cox proportional hazards model for right-censored survival data when the covariates are subject to measurement errors. In Kukush and Chernova (2018) [Theor. Probability and Math. Statist.
Oksana Chernova, Alexander Kukush
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source