Results 1 to 10 of about 28,991 (204)

Bacterial Puppeteering: How the Stealth Bacterium Coxiella Pulls the Cellular Strings [PDF]

Pathogens
Coxiella burnetii, the causative agent of Q fever, is a highly infectious pathogen capable of invading diverse cell types, from alveolar macrophages to trophoblasts. Within host cells, it establishes a replicative niche named Coxiella-containing vacuole (
Dylan Ruart, Juliette Riedinger, Sihem Zitouni, Arthur Bienvenu, Matteo Bonazzi, Eric Martinez   +5 more
doaj   +2 more sources

Clinical value of metagenomic next-generation sequencing in diagnosis of Coxiella burnetii infection [PDF]

BMC Infectious Diseases
Background Metagenomic next-generation sequencing (mNGS) is a new pathogen detection technique, but the current experience of clinical application in Coxiella burnetii infection is relatively limited.
Yuting Luo, Chaohui Zhao, Huili Chen, Ziliang Lin, Jinyu Xia, Xi Liu, Xinghua Li   +6 more
doaj   +2 more sources

Q fever, a rare cause of secondary hemophagocytic lymphohistiocytosis

GMS Infectious Diseases, 2023
Hemophagocytic lymphohistiocytosis (HLH) is a rare syndrome in which is a very infrequent etiology. We present the case of a 62-year-old male with progressive pulmonary infiltrates, fever, hepatitis, and bicytopenia despite broad spectrum antibiotics. A
Nieves Salceda, Juan Francisco, Lozano Cuesta, Pablo, Hermoso de Mendoza Aristegui, Sara, Fernández-Suárez, Jonathan, Madrid Carbajal, Claudia, García Clemente, Marta María   +5 more
doaj   +1 more source

Identification of Type 4B Secretion System Substrates That Are Conserved among Coxiella burnetii Genomes and Promote Intracellular Growth

Microbiology Spectrum, 2023
Coxiella burnetii is a Gram-negative pathogen that infects a variety of mammalian hosts. Infection of domesticated ewes can cause fetal abortion, whereas acute human infection normally manifests as the flu-like illness Q fever.
Charles L. Larson, Willis Pullman, Paul A. Beare, Robert A. Heinzen   +3 more
doaj   +1 more source

The microbiota changes of the brown dog tick, Rhipicephalus sanguineus under starvation stress

Frontiers in Physiology, 2022
Rhipicephalus sanguineus, the brown dog tick, is the most widespread tick in the world and a predominant vector of multiple pathogens affecting wild and domestic animals.
Liping An, Liping An, Biswajit Bhowmick, Biswajit Bhowmick, Dejuan Liang, Dejuan Liang, Penghui Suo, Penghui Suo, Chenghong Liao, Chenghong Liao, Jianguo Zhao, Jianguo Zhao, Qian Han, Qian Han   +13 more
doaj   +1 more source

Sensitive Detection of Antibodies in Patients with Acute Coxiella Burnetii Infection

International Journal of Infectious Diseases, 2022
Purpose: Coxiella burnetii bacteria cause a zoonotic disease called Q fever. Differentiation between acute and chronic Coxiella infection is possible via serological detection of specific antibodies against Coxiella surface lipopolysaccharides, which ...
B. Menge, J.M. Klemens, J. Mentz, K. Dieckmann, S. Saschenbrecker, K.H. Tran, M. Hetherington, K. Steinhagen   +7 more
doaj   +1 more source

Molecular detection of Coxiella spp. in ticks (Ixodidae and Argasidae) infesting domestic and wild animals: with notes on the epidemiology of tick-borne Coxiella burnetii in Asia

Frontiers in Microbiology, 2023
Tick-borne Coxiella spp. are emerging in novel regions infecting different hosts, but information regarding their occurrence is limited. The purpose of this study was the molecular screening of Coxiella spp.
Abid Ali, Muhammad Kashif Obaid, Mashal M. Almutairi, Abdulaziz Alouffi, Muhammad Numan, Shafi Ullah, Gauhar Rehman, Zia Ul Islam, Sher Bahadar Khan, Tetsuya Tanaka   +9 more
doaj   +1 more source

Contributions of lipopolysaccharide and the type IVB secretion system to Coxiella burnetii vaccine efficacy and reactogenicity

npj Vaccines, 2021
Coxiella burnetii is the bacterial causative agent of the zoonosis Q fever. The current human Q fever vaccine, Q-VAX®, is a fixed, whole cell vaccine (WCV) licensed solely for use in Australia. C.
Carrie M. Long, Paul A. Beare, Diane C. Cockrell, Jonathan Fintzi, Mahelat Tesfamariam, Carl I. Shaia, Robert A. Heinzen   +6 more
doaj   +1 more source

Genomic changes during the evolution of the Coxiella genus along the parasitism-mutualism continuum

Peer Community Journal, 2023
The Coxiellaceae family is composed of five genera showing lifestyles ranging from free-living to symbiosis. Among them, Coxiella burnetii is a well-known pathogen causing Q fever in humans.
Santos-Garcia, Diego, Morel, Olivier, Henri, Hélène, El Filali, Adil, Buysse, Marie, Noël, Valérie, McCoy, Karen D., Gottlieb, Yuval, Klasson, Lisa, Zenner, Lionel, Duron, Olivier, Vavre, Fabrice   +11 more
doaj   +1 more source

Coxiella burnetii Sterol-Modifying Protein Stmp1 Regulates Cholesterol in the Intracellular Niche

mBio, 2022
Coxiella burnetii replicates in a phagolysosome-like vacuole called the Coxiella-containing vacuole (CCV). While host cholesterol readily traffics to the CCV, cholesterol accumulation leads to CCV acidification and bacterial death.
Tatiana M. Clemente, Rochelle Ratnayake, Dhritiman Samanta, Leonardo Augusto, Paul A. Beare, Robert A. Heinzen, Stacey D. Gilk   +6 more
doaj   +1 more source