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Seminars in Respiratory and Critical Care Medicine, 2020
AbstractQ fever is a zoonotic infectious disease caused by the Coxiella burnetii bacterium. It is an obligate intracellular pathogen with a high infection capacity that proliferates exclusively in an acidified medium, forming a lysosome-like vacuole. It presents a peculiar phenomenon called “antigenic phase variation,” produced by a modification in the
Pedro Pablo, España +3 more
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AbstractQ fever is a zoonotic infectious disease caused by the Coxiella burnetii bacterium. It is an obligate intracellular pathogen with a high infection capacity that proliferates exclusively in an acidified medium, forming a lysosome-like vacuole. It presents a peculiar phenomenon called “antigenic phase variation,” produced by a modification in the
Pedro Pablo, España +3 more
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2012
Recent proteomic studies of C. burnetii, the etiological agent of Q fever, have brought a deeper insight into the pathogen's physiology and offered new possibilities in investigations of inter- or intra-species relatedness. The data generated from these studies in conjunction with the current genomic sequence databases may reveal additional identities ...
Robert, Ihnatko +2 more
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Recent proteomic studies of C. burnetii, the etiological agent of Q fever, have brought a deeper insight into the pathogen's physiology and offered new possibilities in investigations of inter- or intra-species relatedness. The data generated from these studies in conjunction with the current genomic sequence databases may reveal additional identities ...
Robert, Ihnatko +2 more
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Lipopolysaccharide of Coxiella burnetii
2012A lipopolysaccharide (LPS) is considered to be one of the major determinants of virulence expression and infection of virulent Coxiella burnetii. The LPSs from virulent phase I (LPS I) and from avirulent phase II (LPS II) bacteria were investigated for their chemical composition, structure and biological properties.
Craig T, Narasaki, Rudolf, Toman
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The Coxiella burnetii Parasitophorous Vacuole
2012Coxiella burnetii is a bacterial intracellular parasite of eucaryotic cells that replicates within a membrane-bound compartment, or "parasitophorous vacuole" (PV). With the exception of human macrophages/monocytes, the consensus model of PV trafficking in host cells invokes endolysosomal maturation culminating in lysosome fusion. C.
Ghigo, Eric +2 more
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Isolation of coxiella burnetii in Sweden
Scandinavian Journal of Infectious Diseases, 1991Coxiella burnetii was isolated from sheep placentas, which had been collected from farms harbouring humans seropositive to the organism. The isolation of these bacteria is the final evidence that Q fever is a domestic disease in Sweden.
A, Akesson +5 more
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COXIELLA BURNETII ENDOCARDITIS IN A CHILD
The Pediatric Infectious Disease Journal, 1997Chronic Q fever is a rare but increasingly recognized cause of culture-negative endocarditis in adults. The clinical manifestations of this infection are not well-known in children. In this paper we report Q fever endocarditis in a child.
S, al-Hajjar +3 more
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Gene Inactivation in Coxiella burnetii
2014Coxiella burnetii, the agent of human Q fever, is a zoonotic bacterial pathogen with a worldwide distribution. Owing to an historic lack of methods for genetic manipulation, virulence factors deployed by this bacterium for disease pathogenesis are poorly understood. However, the recent advance of host cell-free (axenic) growth of C.
Paul A, Beare, Robert A, Heinzen
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Annals of the New York Academy of Sciences, 2005
Abstract:Coxiella burnetiiis an obligate intracellular bacterium that causes a worldwide zoonosis, Q fever, and can be misused as a biological warfare agent. Infection in animals (coxiellosis) is mostly persistent. Infection in humans is often asymptomatic, but it can manifest as an acute disease (usually a self‐limited flu‐like illness, pneumonia, or ...
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Abstract:Coxiella burnetiiis an obligate intracellular bacterium that causes a worldwide zoonosis, Q fever, and can be misused as a biological warfare agent. Infection in animals (coxiellosis) is mostly persistent. Infection in humans is often asymptomatic, but it can manifest as an acute disease (usually a self‐limited flu‐like illness, pneumonia, or ...
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Coxiella burnetii Secretion Systems
2012The ability of bacteria to transport proteins across their membranes is integral for interaction with their environment. Distinct families of secretion systems mediate bacterial protein secretion. The human pathogen, Coxiella burnetii encodes components of the Sec-dependent secretion pathway, an export system used for type IV pilus assembly, and a ...
Justin A, McDonough +2 more
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