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Gene Inactivation in Coxiella burnetii
2014Coxiella burnetii, the agent of human Q fever, is a zoonotic bacterial pathogen with a worldwide distribution. Owing to an historic lack of methods for genetic manipulation, virulence factors deployed by this bacterium for disease pathogenesis are poorly understood. However, the recent advance of host cell-free (axenic) growth of C.
Paul A, Beare, Robert A, Heinzen
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Coxiella burnetii Secretion Systems
2012The ability of bacteria to transport proteins across their membranes is integral for interaction with their environment. Distinct families of secretion systems mediate bacterial protein secretion. The human pathogen, Coxiella burnetii encodes components of the Sec-dependent secretion pathway, an export system used for type IV pilus assembly, and a ...
Justin A, McDonough +2 more
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Developmental Biology of Coxiella burnetii
2012The biphasic developmental cycle of Coxiella burnetii is central to the pathogen's natural history and survival. A small, dormant cell morphotype (the small-cell variant or SCV) allows this obligate intracellular bacterium to persist for extended periods outside of host cells, resist environmental conditions that would be lethal to most prokaryotes ...
Michael F, Minnick, Rahul, Raghavan
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Coxiella burnetii Genotypes in Iberian Wildlife
Microbial Ecology, 2016To investigate if Coxiella burnetii, the causative agent of Q fever, genotypes circulating in wildlife are associated with those infecting livestock and humans, multiple-locus variable number tandem-repeat analysis (MLVA-6-marker) was carried out over C.
González-Barrio, David +3 more
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Axenic Growth of Coxiella burnetii
2012Early metabolic studies of C. burnetii showed minimal metabolic activity of axenic (host cell-free) organisms in buffers adjusted to neutral pH. However, our understanding of the organism's physiology was greatly improved upon the discovery that C. burnetii requires an acidic pH for metabolic activation.
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Coxiella burnetii Not a Rickettsia
Microbe Magazine, 2011The recent article describing the outbreak of Q fever in the Netherlands (Microbe, April 2011, p. 159) was both well written and impactful in shedding light on what is very likely an underappreciated cause of febrile illness worldwide, especially where people live in close contact with ruminant livestock. In the article, the causative agent of Q fever,
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Genetic Manipulation of Coxiella burnetii
2012Until very recently, Coxiella burnetii was viewed and studied as an obligate intracellular bacterium that relied exclusively on a eucaryotic host cell for growth. Other medically relevant obligate intracellular bacteria reside in the genera Anaplasma, Chlamydia, Ehrlichia, Orientia, and Rickettsia.
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[Coxiella burnetii osteoarthritis].
Revista clinica espanola, 1992A case of a 25-year-old female characterized by febrile osteoarthritis and arthromyalgias as the only clinical manifestation of a Q fever is discussed. Analytical data were compatible with those of an acute inflammation and serologic findings reached diagnostic levels. Response to Doxycycline treatment was totally satisfactory.
R, Pérez Ortolá +3 more
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