Results 31 to 40 of about 13,384 (274)

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

Comment on “De Novo Reconstruction of 3D Human Facial Images from DNA Sequence”

Advanced Science, EarlyView.
This comment examines AI‐driven DNA‐based facial reconstruction, focusing on the Difface model. While such technologies promise biomedical and forensic applications, they pose significant ethical, legal, and methodological challenges. We emphasize transparency, benchmarking, and rigorous validation to avoid misinterpretation and misuse.
Jennifer K. Wagner, Nina Claessens, Caitlin M. Maloney, Peter Claes   +3 more
wiley   +1 more source

A natural model of spontaneous CP violation

Journal of High Energy Physics, 2022
We examine the possibility of building a natural non-supersymmetric model of spontaneous CP violation equipped with the Nelson-Barr (NB) mechanism to address the strong CP problem.
Sudhakantha Girmohanta, Seung J. Lee, Yuichiro Nakai, Motoo Suzuki   +3 more
doaj   +1 more source

NIR‐Triggered Upconversion‐Perovskite Heterostructures for Non‐Genetic, Implant‐Free Optoelectronic Neuromodulation

Advanced Science, EarlyView.
The Single‐Nanostructured Optoelectronic Vehicle for neuromodulation Activation (SNOVA) establishes a paradigm for non‐genetic, implant‐free neuromodulation. By integrating NIR‐excitable UCNPs with broadband‐absorbing perovskite QDs, SNOVA efficiently converts deeply penetrating light into localized electric fields that modulate neuronal ion dynamics ...
Luyue Jiang, Chenguang Ma, Yiping Zhao, Jiazhi Li, Gen Li, Shuang Jin, Haoyang Su, Ye Tian, Yingkang Yang, Yunfu Luo, Lei Huang, Peijie Chen, Yiming Gao, Yi Wei, Yike Xiang, Lunming Qin, Kaihuan Zhang, Yifei Ye, Pengyi Tang, Liuyang Sun   +19 more
wiley   +1 more source

CP Violation Studies in B Mesons

EPJ Web of Conferences, 2013
The four general purpose detectors on the Tevatron (CDF, D0) and LHC (Atlas, CMS) hadron colliders continue to make important measurements in the field of CP violation (CPV) in B hadron physics. The CDF collaboration presents new results in direct CPV of
Williams Mark R. J.
doaj   +1 more source

CP violation of the loop induced H± → W±Z decays in the general two Higgs doublet model* [PDF]

EPJ Web of Conferences
New sources of CP violation are necessary to solve the problem of the baryon asymmetry of the Universe. Extending the Higgs sector is one way to introduce such new CP violating phases, and studying observables resulting from the CP violation is important
Mura Yushi, Kanemura Shinya
doaj   +1 more source

Population‐Based Multi‐Omics and Cohort Study Identifying Predictive Biomarkers and Therapeutic Targets for Psoriatic Disease

Advanced Science, EarlyView.
Psoriatic disease (PsD) is a chronic skin disease, with challenges in early risk stratification and drug development. Through gene‐level causal inference framework and expression level validation, combined with longitudinal cohort study, CDSN and PRSS8 have been identified as candidate biomarkers and therapeutic targets for PsD.
Tianxing Wu, Jialiang Luo, Haoyuan Qiu, Weijie Shao, Yueyang Lu, Meixuan Luo, Zhaofeng Lin, Yan Zhang, Libo Zhang, Hong Wang, Jia Zhou, Guangfeng Ruan, Peihua Cao, Daming Zuo   +13 more
wiley   +1 more source

Baryogenesis from primordial CP violation

Journal of High Energy Physics
We present a novel baryogenesis mechanism in a three-Higgs doublet model. The lightest doublet plays the role of the standard Higgs, and there are two heavier Higgs bosons.
Venus Keus, Edward W. Kolb
doaj   +1 more source

Inverse Design of Alloys via Generative Algorithms: Optimization and Diffusion within Learned Latent Space

Advanced Intelligent Discovery, EarlyView.
This work presents a novel generative artificial intelligence (AI) framework for inverse alloy design through operations (optimization and diffusion) within learned compact latent space from variational autoencoder (VAE). The proposed work addresses challenges of limited data, nonuniqueness solutions, and high‐dimensional spaces.
Mohammad Abu‐Mualla, Ellis Crabtree, Fredrick Michael, Yayue Pan, Jida Huang   +4 more
wiley   +1 more source

Pseudo-Goldstone dark matter model with CP violation

Journal of High Energy Physics, 2022
We consider an explicitly CP-violating model with two Higgs doublets and one complex singlet scalar. The singlet S is charged under a global U(1) symmetry which is softly broken by a mass term μ 2 S 2 + H.c..
Neda Darvishi, Bohdan Grzadkowski
doaj   +1 more source