Results 151 to 160 of about 77,049 (267)

Liposomal Encapsulation of Camptothecin/Carboxymethyl-β-Cyclodextrin Complexes: Stability, Solubility and Cytotoxicity. [PDF]

Int J Mol Sci
Mesías-Recamán F, Durán-Moreno A, Carmona T, Marcelo G, Mendicuti F.   +4 more
europepmc   +1 more source

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

PAF1c depletion confers chemoresistance to topoisomerase inhibitors. [PDF]

Cell Insight
Li D, Zhu C, Wang T, Chen Q, Chen Q.
europepmc   +1 more source

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source

Ceftaroline for Methicillin-Resistant Staphylococcus aureus Endovascular Infection. [PDF]

Infect Dis Ther
Cosimi RA, Peña K, Lock JL, Riccobene T, Nana B, Sakoulas G.   +5 more
europepmc   +1 more source

Enhancing Tea Agrifood System Resilience Amid Geopolitical Tensions: A Resource Nexus‐Based System Dynamics Analysis

Sustainable Development, EarlyView.
ABSTRACT Geopolitical conflicts are increasingly threatening global food security, economic stability, and peace, impacting Tanzania's tea agrifood system. This study develops a quantitative Resource Nexus‐based system dynamics simulation model assessing the feedbacks and interdependencies among key environmental and socioeconomic resources shaping ...
Ally Mkumbukiy, Daniel Mgori, Edeltraud Guenther, Kaveh Madani   +3 more
wiley   +1 more source

Bipolar Disorder Psychosis Risk Predicts Cue Discrimination on the AX-Continuous Performance Task Paradigm. [PDF]

Bipolar Disord
Fiske M, DiDomenico DL, Chase HW, Afriyie-Agyemang Y, Bebko G, Aslam HA, Graur S, Benjamin O, Wang Y, Stiffler R, Bertocci M, Coffman BA, Sarpal DK, Carter CS, Phillips ML.   +14 more
europepmc   +1 more source

A lysosome‐targeted ultra‐sensitive viscosity probe for monitoring viscosity alterations during chemotherapy

Smart Molecules, EarlyView.
A novel chemosensing platform based on a molecular rotor architecture is established for specific, dynamic detection of lysosomal viscosity. The platform allows real‐time tracking of lysosomal viscosity fluctuations induced by various chemotherapeutic agents, highlighting its significant potential as a powerful tool for early cancer diagnostics and ...
Haoyang Song, Hui Bian, Lei Liu, Gahyeon Park, Bingqing Sun, Qiongzheng Hu, Juyoung Yoon   +6 more
wiley   +1 more source

Cold induced pain elicits reproducible breath metabolomic responses across geographically distinct populations. [PDF]

iScience
Richard M, Singh KD, Sezer D, Buergler S, Palermo L, Schulz Y, Tang Z, Luo X, Frey U, Cattin PC, Li X, Gaab J, Sinues P.   +12 more
europepmc   +1 more source

Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges

The Chemical Record, EarlyView.
Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley   +1 more source