Results 221 to 230 of about 118,210 (303)

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

A systematic review and meta‐analysis of school‐based interventions for PTSD and trauma‐related symptoms: what effective elements they have in common?

open access: yesChild and Adolescent Mental Health, EarlyView.
Background Schools provide critical support for students exposed to traumatic experiences, with school‐based trauma interventions demonstrating reductions in posttraumatic stress symptoms. However, heterogeneity in design, implementation, and efficacy of existing interventions makes it challenging to select suitable interventions and to understand ...
Kirsten Rowlinson   +6 more
wiley   +1 more source

Emotional and behavioural problems of children born preterm and maternal sensitivity: An individual participant data meta‐analysis

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
Abstract Aim To examine whether dyadic maternal sensitivity is associated with emotion and behaviour regulation of children born preterm (< 37 weeks' gestation). Method We performed a systematic literature search and individual participant data (IPD) meta‐analysis including seven cohorts (2469 mother–child dyads).
Elina Jokiranta‐Olkoniemi   +12 more
wiley   +1 more source

Physical therapy interventions for children and adolescents with myelomeningocele: A systematic review

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
Abstract Aim To systematically review the current evidence on physical therapy interventions for children and adolescents with myelomeningocele, the most complex and common presentation of spina bifida, to explore intervention components and the outcomes according to International Classification of Functioning, Disability and Health (ICF) domains, and ...
Lorena Costa Ferreira   +3 more
wiley   +1 more source

Implementing a behavioural intervention for paediatric type 1 diabetes: Key informant perspectives of multilevel barriers and facilitators

open access: yesDiabetic Medicine, EarlyView.
Providers, healthcare leaders, adolescents and caregivers identified evidence of intervention effectiveness in lowering glycaemic levels as a key facilitator of implementing a type 1 diabetes behavioural intervention. Critical barriers to implementation include buy‐in among clinic leaders, resource availability within clinics and meeting families ...
Julia Price   +6 more
wiley   +1 more source

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