Results 41 to 50 of about 785,950 (211)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Lost in the Vaso‐Occlusion: A Patient's Abdominal Pain Returns With a Vengeance

Pediatric Blood &Cancer, EarlyView.
Dunia Hatabah, Martha E. Stewart, Nathan Maassel, James P. Stevens, Claudia R. Morris, Chris A. Rees   +5 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Dermoscopy of lichen aureus Dermatoscopia do liquen aureus

Anais Brasileiros de Dermatologia, 2013
Lichen aureus (also called "lichen purpuricus") is an uncommon subtype of pigmented purpuric dermatosis. Clinically characterized by rust macules, papules or plaques, it is a chronic disease which more often affects young adults and is localized mainly ...
Poliana Santin Portela, Daniel Fernandes Melo, Patricia Ormiga, Felipe José da Cruz Oliveira, Natália Carvalho de Freitas, Cesar Souza Bastos Júnior   +5 more
doaj  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Evaluation of D-dimer serum levels among patients with chronic urticaria, psoriasis and urticarial vasculitis Avaliação dos níveis séricos de D-dímeros entre doentes com urticária crônica, psoríase e urticária vasculite

Anais Brasileiros de Dermatologia, 2013
BACKGROUND: It has been demonstrated that neutrophils, eosinophils and monocytes, under appropriated stimulus, may express tissue factor and therefore, activate the extrinsic pathway of coagulation.
Paulo Ricardo Criado, Lidi Che Leon Antinori, Celina Wakisaka Maruta, Vitor Manoel Silva dos Reis   +3 more
doaj  

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Natriuria and calciuria levels in preeclampsia: a cross-sectional study Valores de natriúria e calciúria na pré-eclâmpsia: estudo transversal

São Paulo Medical Journal, 2013
CONTEXT AND OBJECTIVE Sodium excretion abnormalities in preeclampsia have been studied in relation to several factors. The objective of this study was to compare natriuria (mEq/24 h) and calciuria levels (mg/24 h) in preeclamptic patients.
Rose Gasnier, Edimárlei Gonsales Valério, Janete Vettorazzi, Sérgio Hoffmeister Martins-Costa, Elvino Guardão Barros, José Geraldo Lopes Ramos   +5 more
doaj  

Hemolysin, Biofilm, Enterotoxin, and Exotoxin Genes Prevalence in PVL-Carrying Nasal MRSA from Egyptian Medical Staff and Community Residents

Bulletin of Pharmaceutical Sciences. Assiut University
Staphylococcus aureus commonly colonizes the anterior nares as normal flora; however, community-associated MRSA strains producing the pore-forming Panton–Valentine Leukocidin (pvl) toxin cause severe infections and represent a major public health concern.
Sahar Mandour, Gamal Gad, salah Abdalla, Heba Mohamed, Fatma Mohamed   +4 more
doaj   +1 more source

CR-Cross

, 2023
CR-Cross: A Novel Approach for Cross Domain Coral Recognitions with Reject ...
han han (16826364)
core   +1 more source