Results 31 to 40 of about 621,353 (193)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Valorization and optimization of Pistachio Shell Biochar for Sustainable Reduction of Hexavalent Chromium [Cr(Ⅵ)] [PDF]

open access: yes
In the leather tanning industry, wastewater often contains hazardous hexavalent chromium [Cr(Ⅵ)]. Adsorption is recognized as an effective method for treating this type of wastewater. However, commercial adsorbents can be costly.
Kundu, Nikita   +5 more
core   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

open access: yesMolecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Envelope membrane packed with CTAC modified active carbon for Cr(Ⅵ) removal from aqueous solution

open access: yes, 2020
Polypropylene envelope - type membrane-package was prepared by using cationic surfactant hexadecyl trimethyl ammonium chloride (CTAC) modified coconut-shell activated carbon powder as carrier,and was applied for adsorptive-removal of Cr(Ⅵ) from aqueous ...
鹿文慧   +5 more
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Rapid assessment of soil accessible Cr(Ⅵ) in the field by a portable RGB color sensor

open access: yes
Field rapid determination of soil accessible Cr(Ⅵ) is of great significance for on-site assessment and decision-making about the health risks of contaminated sites.
Jun Jiang   +6 more
core   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

CR submanifolds in Kaehler and nearly Kaehler manifolds [PDF]

open access: yes, 2004
A review of the study of CR, submanifolds within Kaehler and nearly Kaehler manifolds, and the properties of such manifolds with respect submanifold theory in differential geometry.
Gregg, Matthew Thomas
core  

An innovative liquid-injection & solid-stay technology to produce calcium sulfite as long-duration material to control the rebound of Cr(Ⅵ) in remediated groundwater

open access: yes, 2019
raw data for "An innovative liquid-injection & solid-stay technology to produce calcium sulfite as long-duration material to control the rebound of Cr(Ⅵ) in remediated groundwater ...
Li, D
core   +2 more sources

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

open access: yesFEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta   +7 more
wiley   +1 more source

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