Results 51 to 60 of about 606,937 (244)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Comparative Study on Monolithic Zirconia and Lithium Disilicate

Journal of Pharmacy and Bioallied Sciences
Background: In recent years, patient awareness and demands for dental aesthetic have increased tremendously. Aim: To compare between MZ and DL for SR and CR. Material and Method: A total of 64 samples were included and divided into two groups, i.e. A and
Anup Patil, Manish R. Bhise, Shivsharan Dhadde, Lishoy W. Rodrigues, Pratiksha Jadhav, Pushkar Gupta   +5 more
doaj   +1 more source

Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase

Nature Communications, 2023
Monkeypox is a disease with pandemic potential. It is caused by the monkeypox virus (MPXV), a double-stranded DNA virus from the Poxviridae family, that replicates in the cytoplasm and must encode for its own RNA processing machinery including the ...
Jan Silhan, Martin Klima, Tomas Otava, Petr Skvara, Dominika Chalupska, Karel Chalupsky, Jan Kozic, Radim Nencka, Evzen Boura   +8 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Determinasi Harga Saham : Suku Bunga, Current Ratio, ROA, dan DER

Value: Jurnal Manajemen dan Akuntansi
Oil and gas sector companies are experiencing share price growth. This happened after an increase in global crude oil prices. In addition to global crude oil prices, there are many other factors that influence the rise and fall of stock prices.
Annisa Tariza Fitri, Amalia Nur Chasanah, Dian Prawitasari, Vicky Oktavia   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Artificial Insemination Performance Across Different Altitudinal Ecosystems in Serdang Bedagai District, North Sumatera

Jurnal Agripet
Artificial insemination (AI) is one of the key reproductive technologies in beef cattle development, as its success is influenced by multiple factors, including breeder characteristics, technical management, and environmental conditions.
Widiya Mahfuza, Usman Budi, Simon Elieser   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Analyzing the dynamics of changes in demand, production, and cost for lead, tin and chromium

Литьë и металлургия
Developments in electronics and electronic device manufacturing technologies including smartphones, computers and electric cars are significantly affecting demand.
A. S. Panasyugin, N. P. Masherova, I. A. Pankovets, S. V. Martseva, N. D. Pavlovsky   +4 more
doaj   +1 more source