Results 161 to 170 of about 6,088 (266)

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

open access: yesAdvanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong   +20 more
wiley   +1 more source

From gradients to cognition: linking cortical manifolds to brain flexibility and disorder. [PDF]

open access: yesFront Cognit
Nashed JY   +4 more
europepmc   +1 more source

Real‐Time in Vivo Monitoring of Circulating Endometrial Cells: Uncovering Systemic Dissemination and Temporal Fluctuations in Endometriosis

open access: yesAdvanced Science, EarlyView.
A dual‐color pseudo‐menstrual mouse model enables real‐time tracing of circulating endometrial cells (CECs) from uterine and ectopic sources. The study reveals menstrual‐phase‐dependent, burst‐like CEC release, distinct postoperative behaviors of different CEC origins, and a potential association with prolactin fluctuations, providing an in vivo ...
Shang Wang   +15 more
wiley   +1 more source

ANXA1-mediated mTOR/FABP4 Inhibition Drives Antifibrotic Macrophage Reprogramming in Lupus Nephritis. [PDF]

open access: yesInt J Biol Sci
Tao J   +14 more
europepmc   +1 more source

\(CR\)-submanifolds of almost Hermitian manifolds

open access: yes, 1994
\(CR\)-submanifolds are well studied in the case that \((M,g)\) is a Kähler manifold. In this paper, \((M,g)\), in general, is not Kähler. We examine the case of some classes of almost Hermitian manifolds, which generalize the Kähler case. In particular, the more interesting results are obtained for \(CR\)-submanifolds of quasi-Kähler, semi-Kähler, \({\
openaire   +2 more sources

Femtosecond‐Laser Nanocavitation Regenerates SERS‐Active Plasmonic Nanogaps for Longitudinal Molecular Sensing at Biointerfaces

open access: yesAdvanced Science, EarlyView.
A regenerative molecular sensing platform that co‐localizes surface‐enhanced Raman spectroscopy (SERS) sensing and nanocavitation‐based actuation. Femtosecond‐laser triggered nanocavitation produces thermomechanical forces to locally regenerate SERS‐active nanogaps in protein‐rich biofluids while preserving optical performance.
Aditya Garg   +8 more
wiley   +1 more source

Time-resolved IR and X-ray spectroscopy as complementary electronic structure probes of photoinduced ligand-exchange in molybdenum hexacarbonyl.

open access: yesChem Commun (Camb)
Jay RM   +14 more
europepmc   +1 more source

CCL5 hiCD4+ T Cells Regulate Macrophage Polarization and Promote Immunotherapy Response in Bladder Cancer. [PDF]

open access: yesCancer Res
Luo W   +17 more
europepmc   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

open access: yesAdvanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya   +10 more
wiley   +1 more source

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