Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina +11 more
wiley +1 more source
Composite interlaminar fracture toughness: Three-dimensional finite element modeling for mixed mode 1, 2 and 3 fracture [PDF]
A computational method/procedure is described which can be used to simulate individual and mixed mode interlaminar fracture progression in fiber composite laminates.
Chamis, C. C., Murthy, P. L. N.
core +1 more source
Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini +28 more
wiley +1 more source
Influence of load interactions on crack growth as related to state of stress and crack closure [PDF]
Fatigue crack propagation (FCP) after an application of a low-high loading sequence was investigated as a function of specimen thickness and crack closure.
Telesman, J.
core +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Closure of fatigue cracks at high strains [PDF]
Experiments were conducted on smooth specimens to study the closure behavior of short cracks at high cyclic strains under completely reversed cycling. Testing procedures and methodology, and closure measurement techniques, are described in detail.
Dowling, N. E., Iyyer, N. S.
core +1 more source
Arthritis Care &Research, EarlyView.Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo +88 more
wiley +1 more source
Fatigue crack closure: a review of the physical phenomena. [PDF]
Fatigue Fract Eng Mater Struct, 2017 Pippan R, Hohenwarter A.
europepmc +1 more source
On the interaction of ultrasound with cracks: Applications to fatigue crack growth [PDF]
Partial contact of two rough fatigue crack surfaces leads to transmission and diffraction of an acoustic signal at those contacts. Recent experimental and theoretical efforts to understand and quantify such contact in greater detail are discussed.
Buck, O. +2 more
core +1 more source
Investigation of Fatigue Crack Closure（Analysis of Plasticity Induced Crack Closure）
Investigation of Fatigue Crack Closure（Analysis of Plasticity Induced Crack Closure）identifier:oai:t2r2.star.titech.ac.jp ...
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