Results 31 to 40 of about 4,963 (266)
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Fracture and Structural Integrity, 2021 Experimental method for a characterization of high-cycle fatigue evolution of residual stress near cold-expanded hole is developed and implemented. The technique is based on simultaneous measurements of deformation response to narrow notch, inserted in ...
S. I. Eleonsky +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Computation of stress intensity factors by the compliance approach
Computer Assisted Methods in Engineering and Science, 2023 A numerical method based on compliance approach is presented for analyzing an isotropic homogeneous sheet enclosing a crack. The method calculates the strain energy release rate and determines the stress intensity factors KI and KII.
Sameer A. Hamoush, Hisham Abdel-Fattah
doaj
Polymer Testing, 2015 The compliance method is based on simple force-displacement data and is successfully applied to determine fatigue crack propagation in linear elastic, isotropic materials like metals and ceramics. Here, we investigate its potential use in non-linear, time dependent materials like polymers, by comparing its results with those of direct optical tracking ...
Kanters, M.J.W. +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Damage accumulation near the cold-expanded hole due to high-cycle fatigue by crack compliance method
Fracture and Structural Integrity, 2021 The novel destructive method is implemented for quantitative assessment of fatigue damage accumulation in the stress concentration zone accompanied by residual stress due to cold expansion of the through-thickness hole. Damage accumulation is reached by
Sviatoslav Eleonsky +3 more
doaj
Evaluation of the Impact of Residual Stresses in Crack Initiation with the Application of the Crack Compliance Method Part II, Experimental Analysis [PDF]
Applied Mechanics and Materials, 2010 The present work is based on a previous numerical simulation used for the introduction of a residual stress field in a modified compact tensile specimen. The main objective in that paper was to evaluate the effect that previous history has in crack initiation and to establish the new loading conditions needed to propagate a fracture.
G. Urriolagoitia-Sosa +5 more
openaire +1 more source
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source
Evaluation of the Impact of Residual Stresses in Crack Initiation with the Application of the Crack Compliance Method Part I, Numerical Analysis [PDF]
Applied Mechanics and Materials, 2010 The understanding of how materials fail is still today a fundamental research problem for scientist and engineers. The main concern is the assessment of the necessary conditions to propagate a crack that will eventually lead to failure. Nevertheless, this kind of analysis tends to be more complicated, when a prior history in the material is taken into ...
G. Urriolagoitia-Sosa +5 more
openaire +1 more source