Results 101 to 110 of about 129,655 (286)
An improved two-step method based on Kriging model for beam structures
Journal of Low Frequency Noise, Vibration and Active Control, 2019 An improved two-step method for multiple cracks detection in beam structures is presented in this paper. First, the crack locations are identified by the mode shape curvatures.
Xie Fengle +3 more
doaj +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
DronesIn order to solve the problems of low efficiency and accuracy in the traditional detection of tunnel cracks, this paper proposes a tunnel crack detection method based on a UAV (unmanned aerial vehicle) equipped with a high-speed camera and a crack ...
Wei Sun, Xiaohu Liu, Zhiyong Lei
doaj +1 more source
Damage quantification techniques in acoustic emission monitoring [PDF]
, 2011 Acoustic emission (AE) analysis is one of the several diagnostic techniques available nowadays for structural health monitoring (SHM) of engineering structures.
Chan, Tommy H.T. +3 more
core +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
, 2014 An electrical impedance spectroscopy-based nondestructive testing (NDT) method is proposed to image both cracks and reinforcing bars in concrete structures.
Ammari, Habib +3 more
core +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Major challenges in prognostics: study on benchmarking prognostic datasets [PDF]
, 2012 Even though prognostics has been defined to be one of the most difficult tasks in Condition Based Maintenance (CBM), many studies have reported promising results in recent years.
Camci, Faith +2 more
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