Results 111 to 120 of about 130,135 (306)
SensorsCrack detection plays a critical role in ensuring road safety and maintenance. Traditional, manual, and semi-automatic detection methods have proven inefficient.
Mian Zhao +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Abstract The planning, construction, and upkeep of physical structures, including roads, bridges, buildings, and other types of buildings, are the primary responsibilities of civil engineers. Finding cracks and other flaws in structures is one of the more difficult tasks in the field of civil engineering.
openaire +3 more sources
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Transfer Learning-Based Crack Detection by Autonomous UAVs
, 2018 Unmanned Aerial Vehicles (UAVs) have recently shown great performance collecting visual data through autonomous exploration and mapping in building inspection.
Kucuksubasi, Fatih, Sorguc, Arzu
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Auto-checking Device for Locomotive Wheel On-line Crack Detection
机车电传动, 2013 Components and function of locomotive wheel on-line crack detection auto-checking device were introduced. Principle and method of supersonic wave detecting locomotive wheel were described and application of detection device was presented.
LIU Xian
doaj
Major challenges in prognostics: study on benchmarking prognostic datasets [PDF]
, 2012 Even though prognostics has been defined to be one of the most difficult tasks in Condition Based Maintenance (CBM), many studies have reported promising results in recent years.
Camci, Faith +2 more
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source