Results 111 to 120 of about 129,655 (286)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Crack Detection

Abstract The planning, construction, and upkeep of physical structures, including roads, bridges, buildings, and other types of buildings, are the primary responsibilities of civil engineers. Finding cracks and other flaws in structures is one of the more difficult tasks in the field of civil engineering.
openaire   +3 more sources

Enhancing crack detection in railway tracks through AI-optimized ultrasonic guided wave modes

Biomimetic Intelligence and Robotics
The utilization of ultrasonic guided wave technology for detecting cracks in railway tracks involves analyzing echo signals produced by the interaction of cracks with guided wave modes to achieve precise crack localization, which is extremely important ...
Jianjun Liu, Huan Luo, Han Hu, Jian Li
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

An Automated Instance Segmentation Method for Crack Detection Integrated with CrackMover Data Augmentation

Sensors
Crack detection plays a critical role in ensuring road safety and maintenance. Traditional, manual, and semi-automatic detection methods have proven inefficient.
Mian Zhao, Xiangyang Xu, Xiaohua Bao, Xiangsheng Chen, Hao Yang   +4 more
doaj   +1 more source

The influence of cracks in rotating shafts

, 2008
In this paper, the influence of transverse cracks in a rotating shaft is analysed. The paper addresses the two distinct issues of the changes in modal properties and the influence of crack breathing on dynamic response during operation.
A.W. Lees, Adewusi, Bently, Cameron, Chen, Cheung, Darpe, Davies, Dimarogonas, Doebling, Friswell, Gasch, Gounaris, Huang, J-J. Sinou, Jun, Lalanne, Lee, Ling, Mayes, Muszynska, Narayanan, Nayfeh, Penny, Prabhakar, Prabhakar, Pugno, Sekhar, Sekhar, Sekhar, Tsai, Wauer, Wu   +32 more
core   +1 more source

Linear and non-linear dynamic analyses of sandwich panels with face sheet-tocore debonding [PDF]

, 2020
А survey of recent developments in the dynamic analysis of sandwich panels with face sheet-to-core debonding is presented. The finite element method within the ABAQUSTM code is utilized.
Burlayenko, V. N., Sadowski, Tomasz
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Auto-checking Device for Locomotive Wheel On-line Crack Detection

机车电传动, 2013
Components and function of locomotive wheel on-line crack detection auto-checking device were introduced. Principle and method of supersonic wave detecting locomotive wheel were described and application of detection device was presented.
LIU Xian
doaj  

Damage identification on spatial Timoshenko arches by means of genetic algorithms

, 2017
In this paper a procedure for the dynamic identification of damage in spatial Timoshenko arches is presented. The proposed approach is based on the calculation of an arbitrary number of exact eigen-properties of a damaged spatial arch by means of the ...
Cannizzaro, F., D'Urso, D., Greco, A., Pluchino, A.   +3 more
core   +1 more source