Results 71 to 80 of about 130,135 (306)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Detection of curved lines with B-COSFIRE filters: A case study on crack delineation

, 2017
The detection of curvilinear structures is an important step for various computer vision applications, ranging from medical image analysis for segmentation of blood vessels, to remote sensing for the identification of roads and rivers, and to biometrics ...
A Hoover, AF Frangi, AM Mendonca, B Gecer, C Grigorescu, C Lacoste, E Türetken, F Lafarge, G Azzopardi, G Azzopardi, G Azzopardi, J Staal, JVB Soares, ME Martinez-Pérez, N Strisciuglio, N Strisciuglio, P Bibiloni, P Liskowski, Q Li, Q Zou, Y Verdié   +20 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Intelligent Crack Detection and Quantification in the Concrete Bridge: A Deep Learning-Assisted Image Processing Approach

Advances in Civil Engineering, 2022
We proposed a modified concrete bridge crack detector based on a deep learning-assisted image processing approach. Data augmentation technology is introduced to extend the limited dataset.
Licun Yu, Shuanhai He, Xiaosong Liu, Shuqing Jiang, Shuiying Xiang   +4 more
doaj   +1 more source

Statistical Methods for Automatic Crack Detection Based on Vibrothermography Sequence-of-Images Data [PDF]

, 2010
Vibrothermography is a relatively new nondestructive evaluation technique for finding cracks through frictional heat generated from crack surface vibrations under external excitations.
Holland, Stephen, Holland, Stephen, Li, Ming, Meeker, William, Meeker, William   +4 more
core   +4 more sources

Digital image processing of the Ghent altarpiece : supporting the painting's study and conservation treatment [PDF]

, 2015
In this article, we show progress in certain image processing techniques that can support the physical restoration of the painting, its art-historical analysis, or both.
Cornelis, Bruno, Daubechies, Ingrid, De Mey, Marc, Devolder, Bart, Dooms, Ann, Dubois, Hélène, Martens, Maximiliaan, Pizurica, Aleksandra, Platisa, Ljiljana, Ruzic, Tijana   +9 more
core   +2 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Crack Detection with Lamb Wave Wavenumber Analysis [PDF]

, 2013
In this work, we present our study of Lamb wave crack detection using wavenumber analysis. The aim is to demonstrate the application of wavenumber analysis to 3D Lamb wave data to enable damage detection.
Leckey, Cara, Rogge, Matt, Tian, Zhenhua, Yu, Lingyu   +3 more
core   +1 more source

Damage detection in beams from modal and wavelet analysis using a stationary roving mass and noise estimation [PDF]

, 2018
This paper uses the Continuous Wavelet Transform Analysis on mode shapes for damage identification. The wavelet analysis is applied to the difference in the mode shapes between a healthy and a damaged state.
Andreaus, Bendat, Cao, Fan, García, Gentile, Jiang, Katunin, Katunin, Katunin, Katunin, Limongelli, Mallat, Montanari, Ovanesova, Panopoulou, Rajendran, Ren, Rucka, Rucka, Shao, Solís, Solís, Strang, Taha, Ulriksen, Unger, Xu, Xu, Yang, Yi, Zhong, Zhong, Zhong   +33 more
core   +1 more source