Results 81 to 90 of about 130,135 (306)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Effective Crack Damage Detection Using Multilayer Sparse Feature Representation and Incremental Extreme Learning Machine

Applied Sciences, 2019
Detecting cracks within reinforced concrete is still a challenging problem, owing to the complex disturbances from the background noise. In this work, we advocate a new concrete crack damage detection model, based upon multilayer sparse feature ...
Baoxian Wang, Yiqiang Li, Weigang Zhao, Zhaoxi Zhang, Yufeng Zhang, Zhe Wang   +5 more
doaj   +1 more source

Simulation of Impedance Discontinuities Resulting from Degradation of Interconnections on Printed Circuit Boards [PDF]

, 2011
Numerical simulation of impedance discontinuities resulting from degradation of interconnections on printed circuit ...
Dipartimento Di Elettronica, Flavio G. Canavero, Flavio G. Canavero, Michael H. Azarian, Michael H. Azarian, Paolo Manfredi, Paolo Manfredi, Politecnico Di Torino   +7 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Life-cycle of fatigue sensitive structures under uncertainty [PDF]

, 2013
Fatigue is the one of the main contributors to problems related to structural safety of civil and marine structures. Life-cycle management (LCM) techniques considering various uncertainties can be used to predict the safe service life of fatigue ...
Frangopol, Dan M., Soliman, Mohamed
core  

Railway Track Crack Detection

International Journal of Advanced Research in Science, Communication and Technology
This paper presents three innovative solutions for enhancing safety and efficiency in rail transport systems. First, an automated level crossing gate system is proposed, integrating Machine-to-Machine communication and Internet of Things technologies to prevent accidents.
null Mrs. Suma K R, null Chandana H, null Dakshayini H R, null Deeksha C   +3 more
openaire   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Effective small crack detection based on tunnel crack characteristics and an anchor-free convolutional neural network

Scientific Reports
Tunnel cracks are thin and narrow linear targets, and their pixel proportions in images are usually very low, less than 6%; therefore, a method is needed to better detect small crack targets.
Li Wang, Chao Tang
doaj   +1 more source