Results 51 to 60 of about 15,676,159 (315)

Shrinkage-cracking characteristics of biochar-clay mixed soil under dry-wet cycles

Shuiwen dizhi gongcheng dizhi
The integrity and sealing of the landfill cover layer are crucial for its barrier function. Compacted clay is commonly used as a cover material; however, it is prone to shrinkage and cracking under repeated dry-wet cycles, which compromises its ...
Wenjing SUN, Qinghua LI, Yi KONG, Mingyu LI   +3 more
doaj   +1 more source

Strength and crack-resistance of concrete with fibre fillers and modifying nano-additives

Magazine of Civil Engineering, 2023
The article dwells on a comprehensive method for determining concrete strength and crack-resistance in sample testing with varying loading rate. The method allows for receiving simultaneously kinetic parameters of the microstructure defects and length ...
Perfilov Vladimir
doaj   +1 more source

The effect of residual stresses arising from laser shock peening on fatigue crack growth [PDF]

, 2010
Residual stresses have in the past been introduced to manipulate growth rates and shapes of cracks under cyclic loads. Previously, the effectiveness of shot peening in retarding the rate of fatigue crack growth was experimentally studied.
Brennan FP, Chahardehi A, Steuwer A, Brennan, Feargal P., Chahardehi, A., Steuwer, Axel, Brennan, F. P., Chahardehi, Amir Ebrahim, A. Chahardehi, A. Steuwer, F.P. Brennan   +10 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Influence of the Crack Angle on the Deformation and Failure Characteristics of Sandstone under Stepped Cyclic Uniaxial Compression with a Constant Lower Limit

Mathematics, 2023
Engineering rock structures containing joints and fissures are frequently subjected to discontinuous periodic disturbances of varying amplitudes.
Yuanmin Wang, Yunqiang Wang, Song Luo, Hao Liu, Guansheng Yi, Kang Peng   +5 more
doaj   +1 more source

Development Effectiveness Overview (DEO) 2020: Executive Summary

, 2020
The Development Effectiveness Overview (DEO) is an annual report produced by the IDB Group to share the results and impact of its work in Latin America and the Caribbean.
Inter-American Development Bank
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source