Results 71 to 80 of about 15,676,159 (315)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Numerical Simulation of Evolution Mechanism of Rockburst Risk in Deep Rock Tunnels Under Anchor Rod Anchoring

Buildings
The evolution mechanism of the bearing layer in the surrounding rock of tunnels with rockburst risk is extremely complex under bolt anchorage in deep strata.
Xiaojia Chang, Mingming He, Kaiqiang Wu, Mingchen Ding   +3 more
doaj   +1 more source

Fatigue crack shielding in plain bearings under large scale yielding

, 2010
Multi-layered bearing systems used in the automotive industry show shielding and antishielding effects that reduce or amplify the crack driving force under large-scale yielding conditions. Using finite element analysis, it is shown that shielding in such
S. Syngellakis, P.A.S. Reed, Burke-Veliz, A., Reed, P.A.S., Syngellakis, S., A. Burke-Veliz   +5 more
core   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Shear Performance of Reinforced 3DPM-NM Specimens with Different Interface Locking Designs

Buildings
As 3D printing emerges as a transformative technology in construction, the structural performance of 3D-printed mortar (3DPM) has become a key research focus. This study conducted shear tests on reinforced specimens combining 3D-printed mortar (3DPM) and
Chang Sun, Zhipeng Chu, Yijing Luo, Long Li, Qiong Liu, Amardeep Singh   +5 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Macro-mesoscopic developmental patterns of cracks in surrounding rocks of rectangular roadways under true triaxial stresses

Meitian dizhi yu kantan
Objective and MethodThis study aims to investigate the relationship between the stress environment and the deformation and failure responses of surrounding rocks, thereby unraveling the inherent mechanisms underlying the deformation and failure.
Wenbao SHI, Qingzhao XU, Jucai CHANG, Chuanming LI, Longquan QIAO, Zhuang MIAO, Aoyun YAN   +6 more
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

The Influence of Recycled Concrete Aggregate on Crack Development and Bending Capacity of a Reinforced Concrete Beam

Buildings
Recycled Concrete Aggregate (RCA), made of construction and demolition waste, provides a sustainable alternative to natural aggregates. Experimental research using locally available RCA is necessary due to the differences in properties between the ...
Agnessa Nir, Orit Leibovich
doaj   +1 more source

Size effects on residual stress and fatigue crack growth in friction stir welded 2195-T8 aluminium - Part I: Experiments [PDF]

, 2011
Residual stress fields were measured in three different sizes of Compact-Tension (C(T)) and eccentrically loaded single edge notch (ESE(T)) specimens containing transverse or longitudinal welds. The effect of size on residual stress profiles was studied.
Irving, Phil E., P. Staron, T. Fischer, Ma, Yu E., Staron, P., Fischer, T., P.E. Irving, Yu E. Ma   +7 more
core   +1 more source