Results 91 to 100 of about 15,676,159 (315)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
INFLUENCE OF LONGITUDINAL REINFORCEMENT ON DEVELOPMENT OF NORMAL CRACKS
JOURNAL OF CIVIL ENGINEERING AND MANAGEMENT, 2005 Using a model of normal crack propagation in reinforced concrete members, an analytical expression is presented for the stress intensity factor defining the intensity of stress in area at the crack tip. This factor is in linear relationship to the stress in tensile reinforcement, which can be determined by different methods.
Jokūbaitis, Vidmantas, Pukelis, Petras
openaire +3 more sources
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Engineering ProceedingsIn the damage tolerance analysis of aircraft panels, it was necessary to frequently apply complex boundaries and loads to simulate crack propagation. It was difficult to simulate crack propagation with the conventional finite element method.
Wendong Zhang, Xianmin Chen, Jun Yang
doaj +1 more source
CRACK‐NP, development of a model for predicting pollutant transport in cracking clay soils
Soil Use and Management, 2000 Abstract. In cracking clay soils the movement of water and solutes is greatly influenced by the arrangement of cracks and aggregates in the soil profile. It is essential that a model to simulate leaching from clay soils takes into account the routes of water movement and the interaction between water in the ...
Matthews, A. M. +6 more
openaire +1 more source
Concept to predict crack initiation and crack development in fairfaced concrete screeds [PDF]
, 2016 Within a research project of the Laboratory of Solid Structures of the University of Luxemburg, a design concept to predict cracks in various concrete structures will be developed. The current paper presents the numerical investigation of crack initiation and crack development of an unreinforced cementitious fairfaced concrete floor.
WEILER, Michael, WALDMANN, Danièle
openaire +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Development Effectiveness Overview (DEO) 2024
The Development Effectiveness Overview (DEO) is an annual report produced by the IDB Group to share the results and impact of its work in Latin America and the Caribbean.
Inter-American Development Bank
core +1 more source