Results 101 to 110 of about 69,564 (313)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Three-dimensional crack growth in multi-layered architectures for automotive plain bearings
, 2009 The assessment of shielding and anti-shielding effects on crack growth in multi-layered architectures is achieved using elasto-plastic finite element models.
Burke-Veliz, A. +2 more
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Finite element analysis of bonded crack retarders for integral aircraft structures [PDF]
, 2009 Trends in aircraft design and manufacture are towards the reduction of manufacturing cost and structural weight while maintaining high level of safety. These reductions can be achieved by using integral structures.
Boscolo, Marco
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Numerical implementation of the eXtended Finite Element Method for dynamic crack analysis [PDF]
, 2008 A numerical implementation of the eXtended Finite Element Method (X-FEM) to analyze crack propagation in a structure under dynamic loading is presented in this paper.
Pantalé, Olivier +2 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Fatigue crack shielding in plain bearings under large scale yielding
, 2010 Multi-layered bearing systems used in the automotive industry show shielding and antishielding effects that reduce or amplify the crack driving force under large-scale yielding conditions. Using finite element analysis, it is shown that shielding in such
S. Syngellakis +5 more
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Quasi-static crack propagation by Griffith's criterion [PDF]
, 2008 We consider the propagation of a crack in a brittle material along a prescribed crack path and define a quasi-static evolution by means of stationary points of the free energy. We show that this evolution satisfies Griffith's criterion in a suitable form
Negri, Matteo +4 more
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
The cohesive frictional crack model applied to the analysis of the dam-foundation joint [PDF]
, 2010 The mechanical behaviour of dam-foundation joints plays a key role in concrete dam engineering since it is the weakest part of the structure and therefore the evolutionary crack process occurring along this joint determines the global load-bearing ...
Barpi, Fabrizio, Valente, Silvio
core +1 more source