Results 181 to 190 of about 42,379 (316)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

EXPERIMENTAL AND THEORETICAL INVESTIGATIONS ON MODE I CRACK PROPAGATION IN NOTCHES UNDER CYCLIC LOADING

, 2007
Research works regarding crack opening stresses covering various types of Mode I cracks initiated and growing in notches under cyclic loading are shown. A large number of parameters influence the crack opening behavior, i.e. material, crack length, notch
Georgios SAVAIDIS, Georgios TSAMASPHYROS, SAVAIDIS, G, Alexander SAVAIDIS, TSAMASPHYROS, G, KARAGIANNIS, D, SAVAIDIS, A, Dimitrios KARAGIANNIS   +7 more
core  

Surface Treatment, Chemical Characterization, and Debonding Crack Initiation Strength for Veneering Dental Ceramics on Ni-Cr Alloys. [PDF]

Materials (Basel)
Flores-Ferreyra BI, Moyaho-Bernal MLA, Chavarría-Lizárraga HN, Castro-Ramos J, Franco-Romero G, Velázquez-Enríquez U, Flores-Ledesma A, Reyes-Cervantes E, Ley-García AK, Velasco-León EDC, Carrasco-Gutiérrez RG.   +10 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Local and non-local normalised equivalent strain functionals for cyclic fatigue

, 2004
The concept of Cyclic Normalised Equivalent Strain Functionals (CNESnFs) suitable for lowcyclic fatigue is developed in this paper. It reduces any fatigue strength and durability model to a unique form what facilitates the models comparison ...
Mikhailov, SE, S. E. Mikhailov, I. V. Namestnikova, Namestnikova, IV   +3 more
core  

A topological approach to understanding crack initiation and propagation in carbon fiber reinforced polymer composites under an opening load. [PDF]

Sci Rep
Uy M, Kido D, Kimura M.
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

A study of crack initiation in corrosion-fatigue of A.I.S.I 316 stainless steel by dynamic measurement of corrosion characteristics and corrosion current transients

, 1980
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.A technique has been developed and applied to monitor corrosion current transients, in phase with a cyclic stress.
Martin, JW, Martin, J
core  

Role of molecular damage in crack initiation mechanisms of tough elastomers. [PDF]

Proc Natl Acad Sci U S A
Ju J, Sanoja GE, Cipelletti L, Ciccotti M, Zhu B, Narita T, Yuen Hui C, Creton C.   +7 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source