Results 51 to 60 of about 181,401 (307)
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Numerical investigation on the prefabricated crack propagation of FV520B stainless steel
Results in Physics, 2017 FV520B is a common stainless steel for manufacturing centrifugal compressor impeller and shaft. The internal metal flaw destroys the continuity of the material matrix, resulting in the crack propagation fracture of the component, which seriously reduces ...
Juyi Pan, Ming Qin, Songying Chen
doaj +1 more source
Some exact results for the velocity of cracks propagating in non-linear elastic models
, 2006 We analyze a piece-wise linear elastic model for the propagation of a crack in a stripe geometry under mode III conditions, in the absence of dissipation.
E. A. Jagla +6 more
core +1 more source
Influence of woven ply degradation on fatigue crack growth in thin notched composites under tensile loading [PDF]
, 2010 This paper deals with the fatigue of the through the-thickness crack propagation in thin notched composite laminates made of two glass woven plies. It highlights the different crack growths between warp and weft directions of the woven ply.
Barrau, Jean-Jacques +3 more
core +3 more sources
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Scientific Reports, 2023 To investigate the effect of initial cracks on the fatigue performance of high-strength bolts for high-speed train brake discs, the fatigue crack propagation behavior of high-strength bolts under the coupling action of preload and dynamic fatigue load ...
Ping Zhang +3 more
doaj +1 more source
Patterns of Postictal Abnormalities in Relation to Status Epilepticus in Adults
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Abnormalities on peri‐ictal diffusion‐weighted magnetic resonance imaging (DWI‐PMAs) are well‐established for patients with status epilepticus (SE), but knowledge on patterns of DWI‐PMAs and their prognostic impact is sparse. Methods This systematic review and individual participant data meta‐analysis included observational studies ...
Andrea Enerstad Bolle +11 more
wiley +1 more source
Materials & DesignThe fatigue load that a material experiences and its microstructure are important factors influencing fatigue crack propagation behavior. This study employed laser scanning microscopy and electron backscatter diffraction (EBSD) technology, along with ...
Hongtao Chen +5 more
doaj +1 more source