Results 51 to 60 of about 68,107 (316)
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Crack propagation in honeycomb cellular materials: a computational approach
, 2012 Computational models based on the finite element method and linear or nonlinear fracture mechanics are herein proposed to study the mechanical response of functionally designed cellular components. It is demonstrated that, via a suitable tailoring of the
Paggi, M, Paggi, Marco, Marco Paggi
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The influence of crack tip shielding on fatigue crack propagation [PDF]
Fracture and Structural Integrity, 2017 The fatigue crack propagation is one of the major problems and of the real concern in the evaluation of the structural integrity of components. This is due to the fact that once a fatigue crack has been detected it is also known its effect on the ...
Anghel Cernescu
doaj +3 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Development of a fretting-fatigue mapping concept: The effect of material properties and surface treatments [PDF]
, 2009 Fretting-fatigue induced by combined localized cyclic contact motion and external bulk fatigue loadings may result in premature and dramatic failure of the contacting components.
Kubiak, K +3 more
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Scientific Reports, 2023 To investigate the effect of initial cracks on the fatigue performance of high-strength bolts for high-speed train brake discs, the fatigue crack propagation behavior of high-strength bolts under the coupling action of preload and dynamic fatigue load ...
Ping Zhang +3 more
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YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Corrosion Fatigue Crack Propagation Behaviour of a High Strength Low Alloy Steel in a Synthetic Sea Water Environment. [PDF]
, 1986 The corrosion fatigue crack propagation behaviour of a high strength low alloy steel, N-A-XTRA 70, in a synthetic sea water solution was tested using S. E. N. specimens subjected to a loading frequency of 0.1 Hz and a load ratio of 0.6.
Millar, Peter G.
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