Results 91 to 100 of about 445,228 (283)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Concentrated force acting near the tip of an interface crack with a rigid overlay on its side
Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2011 Plane stress state near the tip of an interface crack induced by specified concentrated force is considered. One of the crack faces is partially reinforced by a rigid straight line overlay.
V. V. Sil'vestrov, Yu. O. Vasilieva
doaj +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
3D-2D transition in mode-I fracture microbranching in a perturbed hexagonal close-packed lattice
, 2017 Mode-I fracture exhibits microbranching in the high velocity regime where the simple straight crack is unstable. For velocities below the instability, classic modeling using linear elasticity is valid.
Heizler, Shay I., Kessler, David A.
core +1 more source
Influence of Fatigue Crack Wake Length and State of Stress on Crack Closure [PDF]
, 1988 The location of crack closure with respect to crack wake and specimen thickness under different loading conditions was determined. The rate of increase of KCL in the crack wake was found to be significantly higher for plasticity induced closure in comparison to roughness induced closure. Roughness induced closure was uniform throughout the thickness of
J Telesman, DM Fisher
openaire +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
A note on the cracked plates reinforced by a line stiffener [PDF]
The problem of a cracked plate reinforced by a line stiffener is reconsidered. The original solution of this problem was given in the literature. Also, a variation of the problem with debonding between the plate and the stiffener near the cracked region ...
Erdogan, F., Yahsi, O. S.
core +1 more source
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
DSS-MobileNetV3: An Efficient Dynamic-State-Space- Enhanced Network for Concrete Crack Segmentation
BuildingsCrack segmentation is crucial for health monitoring and preventive maintenance of concrete structures. However, the complex morphologies of cracks and the limited resources of mobile devices pose challenges for accurate and efficient segmentation.
Haibo Li +3 more
doaj +1 more source
Determining stress intensity factor in bending reinforced Concrete beams
Қарағанды университетінің хабаршысы. Математика сериясы, 2019 There has been analytically solved the problem of determining the stress state in the cross section of bending reinforced concrete beams with a crack in a linear formulation.
О. Khabidolda +3 more
doaj +1 more source