Results 101 to 110 of about 445,228 (283)
The crack problem in a specially orthotropic shell with double curvature [PDF]
The crack problem of a shallow shell with two nonzero curvatures is considered. It is assumed that the crack lies in one of the principal planes of curvature and the shell is under Mode I loading condition.
Delale, F., Erdogan, F.
core +1 more source
Fragmentation of a sheet by propagating, branching and merging cracks
, 2015 We consider a model of fragmentation of sheet by cracks that move with a velocity in preferred direction, but undergo random transverse displacements as they move.
Dhar, Deepak
core +1 more source
State-based Prognostics with State Duration Information of Cracks in Structures
Procedia CIRP, 2014 AbstractPrognostics is a key process of Condition-Based Maintenance (CBM) having the ability to forecast the expected future performance of the system/component by calculating its Remaining Useful Life (RUL) under degradation process. This paper presents a state-based prognostic method using state duration information to predict the fatigue life or ...
Eker, Omar F. +3 more
openaire +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
The relationship between observed fatigue damage and life estimation models [PDF]
Observations of the surface of laboratory specimens subjected to axial and torsional fatigue loadings has resulted in the identification of three damage fatigue phenomena: crack nucleation, shear crack growth, and tensile crack growth.
Kurath, Peter, Socie, Darrell F.
core +1 more source
A general boundary-only formula for crack shape sensitivity of integral functionals.
, 1999 This note presents, in the framework of three-dimensional linear elastodynamics in the time domain, a method for evaluating sensitivities of integral functionals to crack shapes, based on the adjoint state approach and resulting in a sensitivity formula ...
Bonnet, Marc
core +3 more sources
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source