Results 111 to 120 of about 445,228 (283)
Reliability-based failure analysis of brittle materials [PDF]
The reliability of brittle materials under a generalized state of stress is analyzed using the Batdorf model. The model is modified to include the reduction in shear due to the effect of the compressive stress on the microscopic crack faces. The combined
Ghosn, Louis J., Powers, Lynn M.
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, 2018 In this work, we study the finite difference approximation for a class of nonlocal fracture models. The nonlocal model is initially elastic but beyond a critical strain the material softens with increasing strain.
Jha, Prashant K., Lipton, Robert
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Stress-intensity factors for a thick-walled cylinder containing an annular imbedded or external or internal surface crack [PDF]
The elastostatic axisymmetric problem for a long thick-walled cylinder containing a ring-shaped internal or edge crack is considered. Using the standard transform technique the problem is formulated in terms of an integral equation which has a simple ...
Erdogan, F., Erdol, R.
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Early Stages of Fatigue Damage of Steels for Fusion Energetics [PDF]
, 2012 Hlavním cílem této práce bylo vysvětlit únavové chování ocelí ODS Eurofer, 14Cr ODS feritické oceli vyráběné v CEA (Commissariat a l’énergie atomique, Saclay, France) a 14Cr ODS feritické oceli vyráběné v EPFL (École Polytechnique Fédérale de Laussane ...
Kuběna, Ivo
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Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
A review of fracture mechanics life technology [PDF]
Current lifetime prediction technology for structural components subjected to cyclic loads was reviewed. The central objectives of the project were to report the current state of and recommend future development of fracture mechanics-based analytical ...
Besuner, P. M. +2 more
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Simulation of fatigue crack growth in d16t alloy using finite element method [PDF]
, 2014 Створено модель плоского зразка з центральною тріщиною в пружно-пластичній постановці за допомогою методу скінченних елементів у програмному комплексі ANSYS.
Galushchak, O. +4 more
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