Results 61 to 70 of about 445,228 (283)

Auxiliary state variables for rotor crack detection

Journal of Vibration and Control, 2010
In the present study, a new model-based method for rotor crack detection and crack location is proposed. The finite-element model of the rotor-bearing system accounts for the breathing mechanism of the crack. The model of the rotor system is augmented with an auxiliary single-degree-of-freedom oscillator.
Zbigniew Kulesza, Jerzy T Sawicki
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Fatigue crack prognosis using Bayesian probabilistic modelling

Mechanical Engineering Journal, 2017
Prognosis of fatigue crack growth for mechanical and structural components is vital for aging military aircraft operated near or beyond their original design lives.
Wenyi WANG, Weiping HU, Nicholas ARMSTRONG   +2 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Prediction of fatigue crack propagation based on dynamic Bayesian network

Advances in Mechanical Engineering, 2022
To address the problem of low prediction accuracy in the current research on fatigue crack propagation prediction, a prediction method of fatigue crack propagation based on a dynamic Bayesian network is proposed in this paper.
Wei Wang, Yanfang Yang, Mengzhen Li, Weikai Liu, Zhiping Liu   +4 more
doaj   +1 more source

Quantization of Crack Speeds in Dynamic Fracture of Silicon: Multiparadigm ReaxFF Modeling [PDF]

, 2007
We report a study of dynamic cracking in a silicon single crystal in which the ReaxFF reactive force field is used for about 3,000 atoms near the crack tip while the other 100,000 atoms of the model system are described with a simple nonreactive force ...
Buehler, Markus J., Goddard, William A., III, Rye, Janet, Tang, Harvey, van Duin, Adri   +4 more
core  

Propagating mode-I fracture in amorphous materials using the continuous random network (CRN) model

, 2011
We study propagating mode-I fracture in two dimensional amorphous materials using atomistic simulations. We used the continuous random network (CRN) model of an amorphous material, creating samples using a two dimensional analogue of the WWW (Wooten ...
David A. Kessler, E. H. Yoffe, Herbert Levine, L. B. Freund, L. I. Slepyan, L. I. Slepyan, Sh. A. Kulamekhtova, Sh. A. Kulamekhtova, Shay I. Heizler   +8 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source