Results 81 to 90 of about 445,228 (283)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Nonlinear lattice model of viscoelastic Mode III fracture

, 2000
We study the effect of general nonlinear force laws in viscoelastic lattice models of fracture, focusing on the existence and stability of steady-state Mode III cracks.
A. Paskin, D. A. Kessler, D. A. Kessler, D. A. Kessler, D. A. Kessler, D. Holland, David A. Kessler, E. Brener, E. Sharon, E. Sharon, Herbert Levine, J. A. Hauch, J. Fineberg, J. Fineberg, J. Fineberg, J. S. Langer, L. I. Slepyan, M. Marder, M. Marder, O. Pla, P. Gumbsch, S. J. Zhou, Sh. A. Kulamekhtova   +22 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

A clamped rectangular plate containing a crack [PDF]

The general problem of a rectangular plate clamped along two parallel sides and containing a crack parallel to the clamps is considered. The problem is formulated in terms of a system of singular integral equations and the asymptotic behavior of the ...
Erdogan, F., Tang, R.
core   +1 more source

ANALYSIS OF STRAIN STATE AND CRACKING OF COCNRETE SLEEPERS

JOURNAL OF CIVIL ENGINEERING AND MANAGEMENT, 2016
Prestressed concrete sleepers are the most common type of the sleepers used on the railroad. They serve as rail supports and absorb loads induced by trains. Sleepers are important for the durability and safety of the railroad and are exposed to various loads and an agressive environment during exploitation.
Jokūbaitis, Aidas, Valivonis, Juozas, Marčiukaitis, Gediminas   +2 more
openaire   +4 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Phase-Field Model of Mode III Dynamic Fracture

, 2001
We introduce a phenomenological continuum model for mode III dynamic fracture that is based on the phase-field methodology used extensively to model interfacial pattern formation.
A. Karma, A. Omeltchenko, Alain Karma, D. A. Kessler, D. A. Kessler, D. A. Kessler, D. A. Kessler, D. Holland, David A. Kessler, E. Johnson, E. Sharon, E. Sharon, F. F. Abraham, G. Caginalp, G. I. Barenblatt, Herbert Levine, I. S. Aranson, J. B. Collins, J. Fineberg, J. Fineberg, J. Fineberg, J. S. Langer, J. S. Langer, J. S. Langer, K. Broberg, K. Ravi-Chandar, L. B. Freund, L. I. Slepyan, L. I. Slepyan, L. I. Slepyan, M. Marder, M. Marder, N. Provatas, P. Gumbsch, S. J. Zhou, Sh. A. Kulamekhtova, T. Cramer, T. Cramer, William H. Press, X.-P. Xu, Z. Pazant   +40 more
core   +1 more source

Fracture mechanics approach to design analysis of notches, steps and internal cut-outs in planar components [PDF]

, 2007
A new approach to the assessment and optimization of geometric stress-concentrating features is proposed on the basis of the correspondence between sharp crack or corner stressfield intensity factors and conventional elastic stress concentration factors (
J Wood, Murakami Y., Neuber H., T. G F Gray, Timoshenko S., Young W. C.   +5 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

The crack problem for a half plane stiffened by elastic cover plates [PDF]

An elastic half plane containing a crack and stiffened by a cover plate is discussed. The asymptotic nature of the stress state in the half plane around an end point of the stiffener to determine the likely orientation of a possible fracture initiation ...
Delale, F., Erdogan, F.
core   +1 more source