Results 61 to 70 of about 1,571 (276)

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

The brittle-to-ductile transition in cold-rolled tungsten sheets: Contributions of grain and subgrain boundaries to the enhanced ductility after pre-deformation

Nuclear Materials and Energy, 2020
One of the key demands on tungsten (W) as designated plasma-facing material (PFM) is the capability to fulfill a structural function. Since W has refused ductilization strategies by alloying alone, the production of W materials with enhanced ductility ...
Carsten Bonnekoh, Philipp Lied, Stefan Zaefferer, Ute Jäntsch, Andreas Hoffmann, Jens Reiser, Michael Rieth   +6 more
doaj   +1 more source

Full-field modelling of crack tip shielding phenomena [PDF]

, 2011
The application of fracture mechanics to engineering design has provided significant advances in understanding of the causes and mechanisms of failure and crack growth.
Lu, Yanwei
core  

Architected Inverse Nacre Hydrogels With High Strength and Crack‐Insensitive Toughness

Advanced Science, EarlyView.
Hydrogels hold promise for biomedical and engineering applications, yet their practical use is fundamentally limited by the strength‐toughness trade‐off and poor fatigue resistance. In this study, a bioinspired inverse nacre architecture constructed via a scalable thermo‐calendering process is introduced, which overcomes these classic limitations ...
Haidi Wu, Qin Su, Cheng Guan, Biwang Pan, Wenjie Hu, Jun Yan, Yifan Feng, Longcheng Tang, Xuewu Huang, Jiefeng Gao, Wancheng Gu   +10 more
wiley   +1 more source

Evaluation of the Mechanical Properties and Fatigue Resistance of the ZrO₂CeYAl₂O₃ Composite

Ceramics
This work aimed to evaluate the fatigue limit of the zirconia ceramic composite stabilized with yttria and ceria reinforced with alumina platelets (ZrO2CeYAl2O3) and characterize the mechanical properties of sintered specimens.
Marcio Paulo de Araújo Mafra, Nélio Silva Júnior, Claudinei dos Santos, Jorge Luiz de Almeida Ferreira, José Alexander Araújo, Cosme Roberto Moreira da Silva   +5 more
doaj   +1 more source

Interaction between line cracks in an orthotropic layer

International Journal of Mathematics and Mathematical Sciences, 2002
We deal with the interaction between three coplanar Griffith cracks located symmetrically in the mid plane of an orthotropic layer of finite thickness 2h. The Fourier transform technique is used to reduce the elastostatic problem to the solution of a set
Subir Das
doaj   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

NET‐DNA Activates the ANXA2/TMEM215/BiP Axis to Promote Mitophagy‐Mediated Anoikis Resistance in Endometriosis

Advanced Science, EarlyView.
NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang, Yanling Gou, Huiyan Zhang, Hongli Wang, Beidi Wang, Jinming Liu, Yingying Cao, Ruru Bai, Yuxin Zhao, Xu Han, Chao Feng, Xin Huang, Zongfeng Zhang   +12 more
wiley   +1 more source

Microsphere‐Modulated Sensing‐in‐Energy Supercapacitor With Self‐Filtering Ultra‐Large Signal Under High‐g Shocks

Advanced Science, EarlyView.
To overcome severe signal oscillation under extreme impact conditions, this work presents a Sensing‐in‐Energy microdevice which integrates a MEMS inertial structure directly within a supercapacitor electrolyte cavity. Utilizing shock‐driven transient contact and electrolyte damping for signal self‐filtering, it achieves weak‐oscillation, large ...
Zhihao Zheng, Yiqun Wang, Kaiyou Liu, Shancheng Luan, Yajiang Yin, Xiaofeng Wang, Keren Dai, Zheng You   +7 more
wiley   +1 more source

Effect of grain structure on fatigue crack propagation behavior of 2024 aluminum alloy under different stress ratios

Materials & Design
The fatigue load that a material experiences and its microstructure are important factors influencing fatigue crack propagation behavior. This study employed laser scanning microscopy and electron backscatter diffraction (EBSD) technology, along with ...
Hongtao Chen, Shuyao Liu, Pai Wang, Xibin Wang, Zhibing Liu, Fadi Aldakheel   +5 more
doaj   +1 more source