Results 121 to 130 of about 647,114 (308)

Line Spring Model and Its Applications to Part-Through Crack Problems in Plates and Shells [PDF]

The line spring model is described and extended to cover the problem of interaction of multiple internal and surface cracks in plates and shells. The shape functions for various related crack geometries obtained from the plane strain solution and the ...
Aksel, B., Erdogan, F.
core   +1 more source

Modeling Lamellar Cracks. [PDF]

, 2013
In this work, studies of models simulating lamellar cracks were conducted. These cracks are formed in rolled sheets with non-metallic inclusions. Studies of lamellar cracks began in the 1960s, but there is still no satisfactory theory explaining their ...
Jaroniek, Mieczysław, Niezgodziński, Tadeusz   +1 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Effect of Drying and Wetting Cycles on the Surface Cracking and Hydro-Mechanical Behavior of Expansive Clays

Buildings
Expansive clays present serious issues in a variety of engineering applications, including roadways, light buildings, and infrastructure, because of their notable volume changes with varying moisture content.
Abdullah A. Shaker, Muawia Dafalla, Ahmed M. Al-Mahbashi, Mosleh A. Al-Shamrani   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Numerical prediction of crack formation in historic masonry buildings

Magazine of Civil Engineering
This article investigated mechanical behavior of the masonry of historic buildings. It was assumed that reliable cracking processes can be obtained by modeling masonry as a continuous medium and using the Jointed Masonry Model (JMM).
Iovlev Gregorii, Belov Nikita, Zileev Aleksandr   +2 more
doaj   +1 more source

ON CRACK CLOSURE IN FATIGUE CRACK GROWTH

, 1978
A brief review of the various forms of closure is given, and the relative importance of plasticity-induced closure and roughness-induced closure is considered. On the basis of the lack of a thickness effect and an insensitivity to R in the absence of closure it is concluded that plasticity-induced closure plays a relatively minor role in affecting the ...
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Fissure evolution and variation of pyrolysis kinetics parameters of tar-rich coal during heat treatment under different atmosphere

Meitan kexue jishu
The clean and efficient development of tar-rich coal is helpful in ensuring China's energy security. The tar-rich coal from Ningtiaota Mine was selected and heated under N2 and hypoxia atmosphere.
Shuangming WANG, Qiang SUN, Xin HU, Zhenlong GE, Jishi GENG, Shengze XUE, Qingmin SHI   +6 more
doaj   +1 more source