Results 111 to 120 of about 647,114 (308)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Maderas: Ciencia y Tecnología, 2012 El objetivo de este trabajo fue localizar el mínimo volumen en árboles de E. nitens que caracterice el comportamiento mecánico y anatómico para un muestreo no destructivo. Los árboles fueron cortados desde Mulchén y Yungay en la región del Bío-Bío.
Paulina Valenzuela C +3 more
doaj
Velocity Fluctuations in Dynamical Fracture: the Role of Microcracks
, 2004 We address the velocity fluctuations of fastly moving cracks in stressed materials. One possible mechanism for such fluctuations is the interaction of the main crack with micro cracks (irrespective whether these are existing material defects or they form
D. A. Kessler +10 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Surface cracks in a plate of finite width under tension or bending [PDF]
The problem of a finite plate containing collinear surface cracks is considered and solved by using the line spring model with plane elasticity and Reissner's plate theory.
Boduroglu, H., Erdogan, F.
core +1 more source
, 2002 We discuss crack propagation along the interface between two dissimilar materials. The crack edge separates two states of the interface, ``stick'' and ``slip''. In the slip region we assume that the shear stress is proportional to the sliding velocity, i.
Brener, Efim A., Marchenko, V. I.
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source