Results 91 to 100 of about 647,114 (308)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Energy radiation of moving cracks

, 2001
The energy radiated by moving cracks in a discrete background is analyzed. The energy flow through a given surface is expressed in terms of a generalized Poynting vector. The velocity of the crack is determined by the radiation by the crack tip.
A. Karma, A. Yuse, D.A. Kessler, D.A. Kessler, D.A. Kessler, D.A. Kessler, E. Louis, E. Louis, E. Sharon, E. Sharon, E. Sharon, E.H. Yoffe, F. Guinea, F.F. Abraham, H. Larralde, I.S. Aranson, J. Fineberg, J. Fineberg, J.A. Hauch, J.F. Boudet, J.F. Boudet, J.F. Boudet, J.F. Boudet, J.M. Morrissey, J.M. Morrissey, J.R. Willis, K.N.G. Fuller, L.B. Freund, L.B. Freund, L.I. Slepyan, L.I. Slepyan, L.M. Sander, M. Adda-Bedia, M. Adda-Bedia, M. Marder, O. Pla, O. Pla, O. Pla, O. Pla, P. González, P. Meakin, R.K. Kalia, S. Fratini, S. Ramanathan, S.J. Zhou, Sh.A. Kulamekhtova, T. Martín   +46 more
core   +1 more source

Reduced models for linearly elastic thin films allowing for fracture, debonding or delamination [PDF]

, 2015
This work is devoted so show the appearance of different cracking modes in linearly elastic thin film systems by means of an asymptotic analysis as the thickness tends to zero.
Babadjian, Jean-Francois, Henao, Duvan
core   +4 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Experimental study of surface cracks [PDF]

, 1972
Analysis of plastic zones surrounding surface cracks in stressed steel and titanium plates subjected to tensile loading shows that back surface dimpling develops at stress levels considerably lower than those predicted by theoretical models of yield zone

core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Experimental Study on the Strength and Damage Characteristics of Cement–Fly Ash–Slag–Gangue Cemented Backfill

Buildings
In order to achieve the goal of effectively utilizing solid waste resources and improving mining stability, it is necessary to incorporate various types of solid wastes in the production of cemented backfill.
Baofeng Song, Heyu Li, Ran An, Xianwei Zhang, Zefeng Zhou   +4 more
doaj   +1 more source