Results 71 to 80 of about 647,114 (308)

Effect of Reinforced Concrete Cracking on Chloride Ion Penetration

MATEC Web of Conferences, 2015
This article is to explore the effect of conditions of reinforced concrete on chloride ion penetration. The influence of the crack width and the thickness of protective layer were studied.
Yuan Chao, Li Yang, Chen Xu, Wang Wenjie
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Deep Learning-Driven Design and Analysis of an Autonomous Robotic System for In-Pipe Inspection

Algorithms
This paper presents an intelligent robotic system for in-pipe inspection that integrates a novel mechanical design, deep learning-based defect detection, and high-fidelity simulation for real-time validation.
Ambigai Rajasekaran, Uma Mohan, Sethuramalingam Prabhu, Shaik Ayman Hameed Baig, Shaik Pasha, Srinivasan Sridhar, Utsav Jain, Arvind Sekhar, Aryan Dwivedi, Praneeth Kasiraju   +9 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Road Crack Detection Using Deep Convolutional Neural Network and Adaptive Thresholding

, 2019
Crack is one of the most common road distresses which may pose road safety hazards. Generally, crack detection is performed by either certified inspectors or structural engineers. This task is, however, time-consuming, subjective and labor-intensive.
Bocus, Mohammud Junaid, Cheng, Shanshan, Fan, Rui, Jiao, Jianhao, Liu, Ming, Ma, Fulong, Wang, Li, Zhu, Yilong   +7 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Crack Segmentation Model Based on Deformable Convolution and Cross‐Stage Feature Fusion Network

IET Intelligent Transport Systems
To address the issues of false positives and missed detections of multi‐scale cracks and small targets in complex environments, this paper proposes an enhanced YOLOv10 instance segmentation network named YOLO‐RCS (YOLOv10s road crack segmentation ...
Mohammed Al‐Soswa, Zhaoyun Sun, Ali Desbi, Abdulkareem Abdullah   +3 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Hot ductility and fracture mechanism of Fe-22Mn-0.7C TWIP steel

工程科学学报, 2016
The static tensile behaviors of Fe-22Mn-0.7C TWIP steel and Q235 steel between 700 ℃ and 1300 ℃ were investigated by Gleeble-1500 thermo-mechanical simulator.The microstructure characteristic and fracture morphology were observed by optical microscopy ...
LAN Peng, TANG Hai-yan, JI Yuan, DU Chen-wei, ZHANG Jia-quan   +4 more
doaj   +1 more source