Results 31 to 40 of about 108,978 (268)

Cracking the system [PDF]

British Journal of General Practice, 2008
I took a moment to listen to his breathing. My heart sank. Even without the aid of a stethoscope, it sounded like stridor and, given his age and past smoking, a bronchial carcinoma until proven otherwise. It had not been an easy trip for my Dad who, accompanied by Mum, had fallen through the system when their first connecting flight from Glasgow had ...
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Investigating diverse photogrammetric techniques in the hazard assessment of historical sites of the Museum of the Coal Basin Area in Będzin, Poland

Reports on Geodesy and Geoinformatics
Assessing the condition of historical sites at risk requires an interdisciplinary approach based on combining multiple measurement technologies. Due to the dynamic development of technology, non-invasive remote sensing methods are gaining significant ...
Świerczyńska Ewa, Karsznia Krzysztof, Książek Krzysztof, Odziemczyk Waldemar   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

THE STUDY OF THE STAGES OF NUCLEATION AND GROWTH OF CRACKS DURING THE FULL-SCALE FATIGUE TEST

Nauka ta progres transportu, 2008
For a railway axle in dependence on stages of crack growth the regular changes of structure of destruction surface during the fatigue tests are presented.
I. O. Vakulenko, M. A. Gryshchenko, O. M. Perkov   +2 more
doaj  

Mechanical Properties of Self-Healing Concrete with Dawson Microcapsule

Buildings
Concrete structure integrity is significantly compromised by the primary problem of cracking. Typically, surface cracking (predominantly shrinkage-induced and thermal microcracking) is rectified using costly and time-consuming repair methods involving ...
Hossein Khosravi, Saeedeh Ghaemifard, Majid Movahedi Rad   +2 more
doaj   +1 more source

Calculation methods analysis of cracked reinforced concrete bending elements curvatures / Supleišėjusių lenkiamųjų gelžbetoninių elementų kreivių skaičiavimo metodų analizė

Mokslas: Lietuvos Ateitis, 2011
This paper describes three methods of curvatures calculating, which are used in STR, EC2 and EMM. Describes, what influence for the average curvature of cracked elements have cracked and uncracked sections in the different methodologies.
Algis Seniūnas
doaj   +1 more source