Results 41 to 50 of about 108,301 (268)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Mechanical Properties of Self-Healing Concrete with Dawson Microcapsule
BuildingsConcrete structure integrity is significantly compromised by the primary problem of cracking. Typically, surface cracking (predominantly shrinkage-induced and thermal microcracking) is rectified using costly and time-consuming repair methods involving ...
Hossein Khosravi +2 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Torsional Behavior of Pylon Columns with Edge Cracks in Suspension Bridges Under Wind Loads
BuildingsCracks inevitably develop in the pylon structures of suspension bridges due to external forces such as wind loads. Cracks are a primary cause of torsional damage to the key supporting structures of suspension bridges.
Nan Liu +7 more
doaj +1 more source
Mokslas: Lietuvos Ateitis, 2011 This paper describes three methods of curvatures calculating, which are used in STR, EC2 and EMM. Describes, what influence for the average curvature of cracked elements have cracked and uncracked sections in the different methodologies.
Algis Seniūnas
doaj +1 more source
Controlled Creation of Contact Cracks in Additive Manufactured Components
Applied Sciences, 2023 Techniques for the controlled seeding and growth of cracks are urgently required for non-destructive testing technique evaluation, particularly for additive manufactured (AM) samples.
Daniel Preston +5 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Concrete crack analysis using a deep belief convolutional neural network [PDF]
Građevinski Materijali i KonstrukcijeThe assessment of surface cracks in concrete structures plays a pivotal role in determining structural integrity. However, current diagnostic technologies suffer from drawbacks such as being time-consuming, subjective, and reliant on inspectors ...
Ramalingam Geetha +3 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source