Results 51 to 60 of about 496,309 (246)

Force‐Electric Nanotentacles of Tantalum Implant Accelerate Cellular Energy Metabolism/Crosstalk for Immunomodulation‐Vascularized Bone Integration

Advanced Science, EarlyView.
A biomimetic force‐electric nanotentacle‐enabled tantalum (Ta) implant with surface‐nanostructured LiTaO3 (n‐LiTaO3) was first developed via laser nanofabrication combined with Li+‐induced in situ reaction, enabling the transduction of ultrasound into bioelectrical cues.
Taixing Zhang, Ke Ma, Kangqing Zuo, Pandong Lin, Tailong Zhang, Rongliang Ding, Linbo Zhang, Aonan Li, Yinchuan Wang, Yanling Huang, Jichao Feng, Guiyong Xiao, Yupeng Lu, Bing Han, Zhiqiang Wang, Ningbo Li   +15 more
wiley   +1 more source

Paradoxical relationship between Mn superoxide dismutase deficiency and radiation-induced cognitive defects. [PDF]

PLoS ONE, 2012
Radiation therapy of the CNS, even at low doses, can lead to deficits in neurocognitive functions. Reduction in hippocampal neurogenesis is usually, but not always, associated with cognitive deficits resulting from radiation therapy.
Rikki Corniola, Yani Zou, David Leu, John R Fike, Ting-Ting Huang   +4 more
doaj   +1 more source

The role of postoperative thoracic radiotherapy and prophylactic cranial irradiation in early stage small cell lung cancer:Patient selection among ESTRO experts [PDF]

, 2019
BACKGROUND: The role of prophylactic cranial irradiation (PCI) and thoracic radiotherapy (TRT) is unclear in resected small cell lung cancer (SCLC).METHODS: Thirteen European radiotherapy experts on SCLC were asked to describe their strategies on PCI and
Slotman, Ben, Troost, Esther G C, Faivre-Finn, Corinne; id_orcid, Glatzer, Markus, Widder, Joachim, Belderbos, José, Houtte, Paul van, Nestle, Ursula, Van Houtte, Paul, Putora, Paul M, Ramella, Sara, Slotman, Ben J., Dziadziuszko, Rafal, Putora, Paul M., Putora, Paul Martin, Troost, Esther G. C., Ruysscher, Dirk de, De Ruysscher, Dirk, Putora, P.M., McDonald, Fiona, Peeters, Stephanie, De Ruysscher, Dirk De, Slotman, Ben J, Ramella, S., Le Pechoux, Cecile, Faivre-Finn, Corinne, Troost, Esther E.G.C., Le Pechoux, Cécile Le, Pöttgen, Christoph, McDonald F, Troost, EGC, Le Pechoux C, Putora, PM, McDonald, F, Glatzer M, Troost EGC, Glatzer, M, Widder, J, Nestle U, De Ruysscher D, Van Houtte P, Slotman, BJ, Widder J, Slotman BJ, Peeters, S, Ramella S, Peeters S, Putora PM, Belderbos J, Le, PC, Ramella, S, Faivre-Finn C, Pottgen, C, Dziadziuszko, R, De, RD, Dziadziuszko R, Pöttgen C, Van, HP, Nestle, U, Belderbos, J   +59 more
core   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Antiepileptic Skin Reactions and Brain Tumors

Pediatric Neurology Briefs, 1999
The frequency of both severe and mild skin reactions in 289 adult patients with brain tumors treated consecutively (1988-93) with cranial radiation and AEDs was studied retrospectively by review of records at the Brigham and Women’s Hospital, Boston, MA.
J Gordon Millichap
doaj   +1 more source

Functional equivalence of stem cell and stem cell‐derived extracellular vesicle transplantation to repair the irradiated brain

Stem Cells Translational Medicine, 2020
Cranial radiotherapy, although beneficial for the treatment of brain tumors, inevitably leads to normal tissue damage that can induce unintended neurocognitive complications that are progressive and debilitating. Ionizing radiation exposure has also been
Sarah M. Smith, Erich Giedzinski, Maria C. Angulo, Tiffany Lui, Celine Lu, Audrey L. Park, Sharon Tang, Vahan Martirosian, Ning Ru, Nicole N. Chmielewski, Yaxuan Liang, Janet E. Baulch, Munjal M. Acharya, Charles L. Limoli   +13 more
doaj   +1 more source

Near‐Infrared Fluorescent PROTAC Enables Theranostic Imaging and Selective Tau Degradation in Alzheimer's Disease

Advanced Science, EarlyView.
Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren, Qian Yue, Ning Gao, Qiu‐Lian Hao, Yan Huo, Chuchu Li, Xinyue Leng, Lu‐Lu Sun, Maggie Pui Man Hoi, Hai‐Hao Han, Mingliang Ma, Xu‐Wen Li   +11 more
wiley   +1 more source

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

Changes in epigenetic markers, DNMT1 and HDAC1/2, in the adult mouse hippocampus after cranial irradiation

, 2017
Brain exposure to ionizing radiation can cause functional deficits in the hippocampus, including memory impairment. However, the specific molecular mechanisms underlying irradiation-induced cognitive impairments are largely unknown.
Miyoung Yang, C Moon, Jong-Choon Kim, J S Kim, M Yang, S H Kim, Yeonghoon Son, Sung-Ho Kim, Juhwan Kim, S Kang, J C Kim, Changjong Moon, Joong-Sun Kim, Uhee Jung, Sueun Lee, J Kim, U Jung, S Lee, Sohi Kang   +18 more
core   +1 more source

Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications

Advanced Science, EarlyView.
Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen, Jiahui Lai, Qiongjiao Zeng, Liangbin Zhou, Boguang Yang, Bin Zhang, Min Wang, Jiajing Zhou, Kieran Lau, Khoon S. Lim, Zhong Alan Li, Rocky S. Tuan   +11 more
wiley   +1 more source