Results 101 to 110 of about 108,126 (340)

Next-Generation Cranial Nerve Stimulation and Neuromodulation Techniques: Potential and Clinical Applications in Parkinson’s Disease Treatment [PDF]

, 2023
Kaan Tuğberk Özdemir
openalex   +1 more source

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, EarlyView.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

Advanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang, Shuang Li, Man Li, Wenke Zhou, Jianqing Zhang, Zhenfu Wu, Zhaoqi Mao, Juan Wan, Xinhao Tang, Baoping Zheng, Qiang Liu, Zhendong Li, Xiaobing Jiang, Qingping Wu, Youfan Ye, Haijun Wang   +15 more
wiley   +1 more source

Effcacy and safety of nerve growth factor for the treatment of neurological diseases: a meta-analysis of 64 randomized controlled trials involving 6,297 patients

Neural Regeneration Research, 2015
OBJECTIVE: China is the only country where nerve growth factor is approved for large-scale use as a clinical medicine. More than 10 years ago, in 2003, nerve growth factor injection was listed as a national drug.
Meng Zhao, Xiao-yan Li, Chun-ying Xu, Li-ping Zou   +3 more
doaj   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Neurological, Cognitive, and Psychological Findings Among Survivors of Ebola Virus Disease From the 1995 Ebola Outbreak in Kikwit, Democratic Republic of Congo: A Cross-sectional Study. [PDF]

, 2019
BackgroundClinical sequelae of Ebola virus disease (EVD) have not been described more than 3 years postoutbreak. We examined survivors and close contacts from the 1995 Ebola outbreak in Kikwit, Democratic Republic of Congo (DRC), and determined ...
Bjornson, Zach, Bramble, Matthew S, Glymour, M Maria, Hoff, Nicole A, Kelly, J Daniel, McIlwain, David, Mukadi, Patrick, Musene, Kamy, Muyembe-Tamfum, Jean Jacques, Nolan, Garry P, Okitolonda-Wemakoy, Emile, Okitundu, Daniel, Porco, Travis C, Rimoin, Anne W, Rutherford, George W, Spencer, D'Andre   +15 more
core  

International Guillain-Barré Syndrome Outcome Study (IGOS): protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barré syndrome [PDF]

, 2017
Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy with a highly variable clinical presentation, course, and outcome. The factors that determine the clinical variation of GBS are poorly understood which complicates the care and treatment of
Bateman, K., Chavada, Govindsinh, Cornblath, D. R., Cornblath, David R., Dardiotis, E., Faber, C. G., Feasby, T. E., Gorson, K. C., Gorson, Kenneth C., Harbo, T., Harbo, Thomas, Hartung, H. P., Hartung, H. P., Hartung, Hans Peter, Hughes, R. A.C., Hughes, Richard A.C., Illa, I., Islam, B., Islam, Z., Jacobs, B. C., Jacobs, B. C., Jacobs, B. C., Jacobs, Bart C., Kusunoki, S., Kusunoki, S., Kusunoki, Susumu, Lehmann, H. C., Mohammad, Q. D., Nobile-Orazio, E., Péréon, Y., Reddel, S. W., Reisin, R. C., Roodbol, J., Shahrizaila, N., van den Berg, B., van den Berg, B., van den Berg, Bianca, van den Bergh, P., van der Kooi, A. J., van Dijk, G. W., van Doorn, P. A., van Doorn, Pieter A., van Woerkom, M., Verboon, C., Verboon, C., Verboon, Christine, Visser, L. H., Wang, Y. Z., Willison, H. J., Willison, Hugh J.   +49 more
core   +3 more sources

Magnetic Resonance Imaging Reveals Meningeal Lymphatic Impairment in Lung Adenocarcinoma Brain Metastasis Progression

Advanced Science, EarlyView.
This study demonstrates meningeal lymphatic impairment associated with lung adenocarcinoma brain metastasis progression in both human patients and mouse models, establishes clinically applicable non‐invasive imaging biomarkers for quantitative analyzing mLV structure and function, and reveals mLVs as robust prognostic indicators and promising potential
Yuan Zhang, Shucheng Jin, Penghui Guo, Yuying Yin, Yichun Hua, Xiaosheng Ding, Zhe Zhang, Shuo Chen, Xu Han, Baowang Li, Yan Liu, Xiaoyan Li, Deling Li, Jing Jing, Wei Shi, Wang Jia   +15 more
wiley   +1 more source

A Comprehensive Review on Oculomotor Nerve Palsy: Diagnosis and Management Strategies

Journal of Modern Rehabilitation
The third cranial nerve (oculomotor nerve) plays an essential role in the function of ocular movement and mainly innervates the inferior oblique, medial rectus, inferior rectus, superior rectus, levator palpebrae, pupillary sphincter, and ciliary muscle.
Yasir Adil Shakor, Raheleh Moravvej, Ali Majdi, Razieh Bahreini   +3 more
doaj   +1 more source

Varicella-zoster virus infections – antiviral therapy and diagnosis

GMS Infectious Diseases, 2016
Varicella-zoster virus is an important human pathogen that causes varicella after primary infection and zoster after recurrence. Following primary infection, the virus remains latently for life in dorsal root and cranial nerve ganglia.
Sauerbrei, Andreas
doaj   +1 more source