Results 111 to 120 of about 73,813 (262)

Cannabidiol reduces atypical absence seizures and epileptic spasms in a Gabrb3+/D120N mouse model of Lennox–Gastaut syndrome

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Lennox–Gastaut syndrome (LGS) is a drug‐resistant developmental and epileptic encephalopathy (DEE). Preclinical drug development for LGS is constrained by a lack of syndrome‐relevant animal models. We aimed to evaluate a Gabrb3+/D120N knock‐in (KI) mouse model of LGS by quantifying atypical absence seizures and epileptic spasms and ...
Thomas Harman   +5 more
wiley   +1 more source

VII. Respiratory Disease and Cranial Nerve Disorders

open access: yesNihon Naika Gakkai Zasshi, 2012
Matsunaga, Kazuto, Ichinose, Masakazu
openaire   +2 more sources

Complete lesion resection and early surgical intervention are favorable factors for long‐term seizure freedom in drug‐resistant epileptic spasms

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Epileptic spasms (ES) in children carry a high risk of neurodevelopmental delay, yet predictors of long‐term surgical outcome remain incompletely defined. This study aimed to evaluate seizure outcomes following epilepsy surgery and to identify independent prognostic factors for postoperative recurrence.
Hua Li   +7 more
wiley   +1 more source

Trendelenburg positioning with or without norepinephrine infusion for haemodynamic support in anaesthetised hypovolemic horses

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Intraoperative haemorrhage during equine anaesthesia is a rare but potentially fatal complication requiring prompt haemodynamic support. Postural manoeuvres such as Trendelenburg (TL) positioning and vasopressor support augment venous return and improve cardiac output (CO), yet their efficacy in anaesthetised hypovolemic horses ...
Vaidehi V. Paranjape   +3 more
wiley   +1 more source

Chronic Inflammatory Demyelinating Polyneuropathy with Atypical Symptoms: A Rare Case of Tongue Fasciculation and Facial Muscle Weakness

open access: yesPakistan Journal of Medical Research
This case report presents a 55-year-old man, with a history of hypertension, who developed an unusual and atypical presentation of chronic inflammatory demyelinating polyneuropathy (CIDP). Over 3 months, the patient experienced progressive limb weakness
Shafiq ur Rehman, Saba Zaidi, Mahzareen
doaj   +2 more sources

Piezosurgical partial ostectomy of the incisive bone for an ossifying fibroma removal in a 4‐year‐old Warmblood gelding

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Ossifying fibromas are uncommon in horses and complete surgical excision with premaxillectomy, maxillectomy or mandibulectomy is recommended. Piezosurgery has been previously used in equines only in one study. Objective To report a case of ossifying fibroma treated with piezosurgery and to describe its follow‐up.
G. Forni   +3 more
wiley   +1 more source

Radiographic identification and description of the equine middle conchal sinus (ethmoidal sinus): Implications for diagnosing middle conchal sinusitis

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background The middle conchal sinus (MCS) (ethmoidal sinus) remains one of the least understood equine paranasal compartments. Despite recognition of its involvement in sinonasal disease, disorders of the MCS often remain underdiagnosed in the absence of computed tomographic (CT) imaging due to limited anatomical understanding and challenges ...
J.‐B. Pavard   +3 more
wiley   +1 more source

Arterial Perivascular Space‐Mediated Solute Transport in the Mouse Brain

open access: yesExploration, EarlyView.
The mechanisms underlying solute clearance from the brain parenchyma remain debated, with competing hypotheses involving bulk cerebrospinal fluid flow versus perivascular transport. Using multimodal in vivo imaging and computational modeling in mice, this study demonstrates that arterial pulsation drives bidirectional solute movement within the ...
Shiyong Li   +9 more
wiley   +1 more source

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