Results 31 to 40 of about 2,247 (229)

Dental Age, Agenesis, and Morphology in Patients With Operated Single-Suture Craniosynostoses [PDF]

, 2020
Peer ...
Sami Leinonen, David Rice, Junnu Leikola, Arja Heliövaara   +3 more
openalex   +4 more sources

Apparently synonymous substitutions in FGFR2 affect splicing and result in mild Crouzon syndrome [PDF]

, 2014
Background: Mutations of fibroblast growth factor receptor 2 (FGFR2) account for a higher proportion of genetic cases of craniosynostosis than any other gene, and are associated with a wide spectrum of severity of clinical problems.
Fenwick, A.L. (Aimée), Goos, J.A.C. (Jacqueline), Hoogeboom, A.J.M. (Jeannette), Lester, K.J. (Kathryn), Lord, H. (Helen), Mathijssen, I.M.J. (Irene), Ouweland, A.M.W. (Ans) van den, Rankin, J. (Julia), Wall, S.A. (Steven), Wilkie, A.O.M. (Andrew)   +9 more
core   +5 more sources

Dexmedetomidine as an Opioid-Sparing Agent in Pediatric Craniofacial Surgery

Children, 2020
Pediatric craniofacial reconstruction surgery is associated with significant perioperative analgesic requirements. As dexmedetomidine mediates central nervous system sympathetic activity and pain modulation, its intraoperative use could be beneficial in ...
Srijaya K. Reddy, Jacob J. Jones, Heather Gordish-Dressman, Sophie R. Pestieau   +3 more
doaj   +1 more source

Polycystin‐1 modulates RUNX2 activation and osteocalcin gene expression via ERK signalling in a human craniosynostosis cell model

Journal of Cellular and Molecular Medicine, Volume 25, Issue 7, Page 3216-3225, April 2021., 2021
Abstract Craniosynostosis refers to the premature fusion of one or more cranial sutures leading to skull shape deformities and brain growth restriction. Among the many factors that contribute to abnormal suture fusion, mechanical forces seem to play a major role.
Maira Katsianou, Kostas A. Papavassiliou, Ilianna Zoi, Antonios N. Gargalionis, Dimitrios Panagopoulos, Marios S. Themistocleous, Christina Piperi, Athanasios G. Papavassiliou, Efthimia K. Basdra   +8 more
wiley   +1 more source

Effects of Thyroxine Exposure on Osteogenesis in Mouse Calvarial Pre-Osteoblasts [PDF]

, 2013
The incidence of craniosynostosis is one in every 1,800-2500 births. The gene-environment model proposes that if a genetic predisposition is coupled with environmental exposures, the effects can be multiplicative resulting in severely abnormal phenotypes.
A Mansukhani, AK Coussens, BD Stamper, BK Huang, BU Ang, C Owen, C Yao, CB Harvey, CH Shackleton, CW Li, D Gomez, D Johnson, DC Robinson, DP Rice, DT Gault, G Radetti, G Ramajayam, GA Brent, GM Morriss-Kay, GR Williams, H Kohara, H Miraoui, HJ Kim, J Connerney, J Esparza, J Zumbrunn, JA Greenwald, Jack C. Yu, James J. Cray, JH Bassett, JH Oh, JL Penfold, JM Britto, JQ Feng, JS Morey, K Kasono, KA Kapp-Simon, Kameron Khaksarfard, KM Lee, M Bodo, M Menking, M Segni, MH Sheng, MM Cohen Jr, Mohammed Elsalanty, PJ Marie, R Rice, S Akita, S Wadhwa, S Weiss, SA Boyadjiev, SA Rasmussen, Seth M. Weinberg, W Arlt, W Riggs Jr, WM Chadduck, Xing-Ming Shi, Y Xiong, Z von Marschall   +58 more
core   +2 more sources

Lessons from joint development for cartilage repair in the clinic

Developmental Dynamics, Volume 250, Issue 3, Page 360-376, March 2021., 2021
Abstract More than 250 years ago, William Hunter stated that when cartilage is destroyed it never recovers. In the last 20 years, the understanding of the mechanisms that lead to joint formation and the knowledge that some of these mechanisms are reactivated in the homeostatic responses of cartilage to injury has offered an unprecedented therapeutic ...
Anne‐Sophie Thorup, Francesco Dell'Accio, Suzanne E. Eldridge   +2 more
wiley   +1 more source

Crouzon’s syndrome with adenotonsillitis: conventional surgery in altered anatomy. [PDF]

, 2013
Background/Objectives: Crouzon’s syndrome is characterized by premature closure of the cranial sutures, midface hypoplasia, orbital deformities & other associated abnormalities.Children with Crouzon syndrome frequently have obstructive sleep apnea ...
Appaji, Mohan, Devi, Pinky, MK, Goutham, Naik, Sarika s, Naik, Sudhir M, S, Ravishankar, SM, Annapurna   +6 more
core   +2 more sources

2b or Not 2b: How Opposing FGF Receptor Splice Variants Are Blocking Progress in Precision Oncology

Journal of Oncology, Volume 2021, Issue 1, 2021., 2021
More than ten thousand peer‐reviewed studies have assessed the role of fibroblast growth factors (FGFs) and their receptors (FGFRs) in cancer, but few patients have yet benefited from drugs targeting this molecular family. Strategizing how best to use FGFR‐targeted drugs is complicated by multiple variables, including RNA splicing events that alter the
Richard J. Epstein, Li Jun Tian, Yan Fei Gu, Chandra Singh   +3 more
wiley   +1 more source

FGF2 is expressed in human and murine embryonic choroid plexus and affects choroid plexus cell behaviour [PDF]

, 2008
Background Although fibroblast growth factor (Fgf) signalling plays crucial roles in several developing and mature tissues, little information is currently available on expression of Fgf2 during early choroid plexus development and whether Fgf2 directly ...
Ferretti, P., Greenwood, S., Swetloff, A., Terasaki, T., Wade, A.   +4 more
core   +3 more sources

Volumetric lipoinjection of the fronto-orbital and temporal complex with adipose stem cells for the aesthetic restoration of sequelae of craniosynostosis

Archives of Plastic Surgery, 2018
Background Non-syndromic craniosynostosis causes craniofacial asymmetry and may persist after cranioplasty. These postoperative asymmetries are primarily depressions.
Yanko Castro-Govea, Amin Vela-Martinez, Luis Alberto Treviño-Garcia   +2 more
doaj   +1 more source